S
Steven R. Lear
Researcher at University of California, San Francisco
Publications - 28
Citations - 2481
Steven R. Lear is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cholesterol & Sterol O-acyltransferase. The author has an hindex of 20, co-authored 28 publications receiving 2380 citations. Previous affiliations of Steven R. Lear include United States Department of Veterans Affairs.
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Journal ArticleDOI
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Sylvaine Cases,Steven J. Smith,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Eric Sande,Sabine Novak,Colin Collins,Carrie B. Welch,Aldons J. Lusis,Sandra K. Erickson,Robert V. Farese +11 more
TL;DR: An expressed sequence tag clone that shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fatty acyl coA as a substrate was identified, which will greatly facilitate studies of cellular glycerolipid metabolism and its regulation.
Journal ArticleDOI
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase ITS CLONING, EXPRESSION, AND CHARACTERIZATION
Sylvaine Cases,Sabine Novak,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Steven R. Lear,Eric Sande,Carrie B. Welch,Aldons J. Lusis,Thomas A. Spencer,Brian R. Krause,Sandra K. Erickson,Sandra K. Erickson,Robert V. Farese +13 more
TL;DR: A second mammalian ACAT enzyme is described, designated ACAT-2, that is 44% identical to the first cloned mouse ACAT (henceforth designated ACat-1) and will facilitate molecular approaches to understanding the role of ACAT enzymes in mammalian biology.
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Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Sandra K. Erickson,Sandra K. Erickson,Steven R. Lear,Sean Deane,Sandrine Dubrac,Sandra Huling,Lien Nguyen,Jaya Bollineni,Sarah Shefer,Hideyuki Hyogo,David E. Cohen,Benjamin L. Shneider,Ephraim Sehayek,Meena Ananthanarayanan,Natarajan Balasubramaniyan,Fredrick J. Suchy,Ashok K. Batta,Gerald Salen,Gerald Salen +18 more
TL;DR: The data suggest that cyp7A1 deficiency results in a proatherogenic phenotype in both genders and leads to a prolithogenic phenotype in females.
Journal ArticleDOI
Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations
TL;DR: A method was designed to determine quantitatively the amounts of these important side-chain oxysterols by derivatization to the Delta4-3-ketones followed by high performance liquid chromatography and was used to determine the concentrations of these oxysterol in rodent liver under various physiological conditions.
Journal ArticleDOI
Effect of Essential Fatty Acid Deficiency on Cutaneous Sterol Synthesis
Kenneth R. Feingold,Kenneth R. Feingold,Barbara E. Brown,Barbara E. Brown,Steven R. Lear,Steven R. Lear,Arthur H. Moser,Arthur H. Moser,Peter M. Elias,Peter M. Elias +9 more
TL;DR: Evidence is provided that epidermal sterologenesis is not entirely autonomous, and can be regulated by water barrier requirements, and de novo synthesis of cholesterol and total nonsaponifiable lipids in essential fatty acid-deficient mice.