Yaron Vinik

TL;DR: Ferroptosis was induced at low drug doses and was associated with increased cellular iron and decreased glutathione levels, concomitant with reduced levels of GPX4 and key glutathion biosynthesis genes.

TL;DR: A relatively low-cost, fast, and reliable method to isolate sEVs from plasma of BC patients and analyze their protein content by semiquantitative proteomics revealed a signature of seven proteins that differentiated BC patients from healthy individuals, of which FAK and fibronectin displayed high diagnostic accuracy.

TL;DR: These findings identify galectins as new players in osteoclastogenesis and bone remodeling, and highlight a potential regulation of bone mass by animal lectins.

TL;DR: Vinik et al. as discussed by the authors showed that mice overexpressing galectin-8, a secreted mammalian lectin of the galectins family, exhibit accelerated osteoclasts activity and bone turnover, which culminates in reduced bone mass, similar to cases of postmenopausal osteoporosis and cancerous osteolysis.

TL;DR: Use of dispersed human islets provides a new platform for functional HTS in a highly physiological system and identifies new targets, such as OTUB2, for therapeutic intervention in type 1 diabetes and islet transplantation.