Showing papers in "Neuroscience Letters in 2009"

TL;DR: This study shows that high spelling accuracy can be achieved with the P300 BCI system using approximately 5 min of training data for a large number of non-disabled subjects, and that the RC paradigm is superior to the SC paradigm.

TL;DR: The results suggest that unless specifically stabilized, certain brain-enriched miRNAs represent a rapidly executed signaling system employing highly transient effectors of CNS gene expression, and that in AD temporal lobe neocortex specific brain mi RNAs are significantly up-regulated in abundance and strongly correlate with the presence of AD-type neuropatholgical change.

TL;DR: It is proposed that iPSCs can be induced to differentiate into retinal cells which have a possibility to be used as patient-specific donor cells for transplantation therapies.

TL;DR: It is demonstrated that the pattern of functional connectivity of the motor network in the resting state is disrupted in PD, and this change is secondary to dopamine deficiency, and related to the severity of the disease.

TL;DR: Insight is provided into the organization of human AIC and a methodological approach that may be further used to refine the emerging functional map of the insular cortex is provided.

TL;DR: This mini-review focuses on possible cellular and molecular mechanisms of interaction of MSCs with glia, neurons and vessels after brain attack, and opens up new avenues of cell therapy and may provide an effective treatment for various CNS diseases.

TL;DR: Functional connectivity data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing, and hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing current understanding of abnormal development of neural circuitry in adolescents with MDD.

TL;DR: A novel ELISA is described that allows for quantification of alpha-syn in CSF down to 50pg/mL and suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation.

TL;DR: Subjects' reaction time performance indicated that they did implicitly learn the exposed sequences, and furthermore, this learning was unrelated to explicit learning.

TL;DR: Alpha-Syn in mitochondria is differentially expressed in different brain regions and the background levels of mitochondrial alpha-Syn may be a potential factor affecting mitochondrial function and predisposing some neurons to degeneration.

TL;DR: A large voxel-based meta-analysis of current functional magnetic resonance imaging (fMRI) studies employing emotional faces paradigms in healthy volunteers found no support for the hypothesis of overall right-lateralization of emotional processing.

TL;DR: This adaptive filter procedure proved a reliable and efficient tool to remove ECG artefact from surface EMGs with mixed and varied patterns of transient, short and long lasting dystonic contractions.

TL;DR: These studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease.

TL;DR: The results suggested that the alteration of DAN might underpin the impairment of top-down attention function in mTLE, and may contribute to the understanding of neuro-pathophysiological mechanism of attention impairments in patients with mTle.

TL;DR: Evidence is provided that BM-MSCs can promote the reduction of Abeta through the microglial activation in this acutely induced AD brain, suggesting a potential therapeutic agent against AD.

TL;DR: The results show a significant cumulative effect of tDCS on modifying smoking cue-provoked craving, and confirm the notion that tDCS has a specific effect on craving behavior and that the effects of several sessions can increase the magnitude of its effect.

TL;DR: The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin -1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake.

TL;DR: The results suggest that GTA is a useful tool in defining dysregulated neural networks even during rest, and may contribute to decrease self-control, impaired inhibitory function as well deficits in stress regulation in chronic heroin users.

TL;DR: Findings implicate defective Akt as a putative signalling pathway linked to loss of dopaminergic neurons in PD.

TL;DR: The neuroimaging findings indicate that the left superior and lateral frontal regions (BA8/9) are common neural correlates of regulation of both emotions, and there are shared as well as valence-specific neurocognitive mechanisms underlying regulation of positive and negative emotions.

TL;DR: An rtfMRI-based brain-machine interface (BMI) whereby 2-dimensional movement of a robotic arm was controlled by the regulation of regional cortical activations in the primary motor areas.

TL;DR: Results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents.

TL;DR: Considering the pivotal role for kisspeptin signalling in the activation of the HPG axis, the ability of gh Relin to down-regulate Kiss1 expression in mPOA may be a contributing factor in ghrelin-related suppression of pulsatile LH secretion.

TL;DR: The results showed that BDNF levels were decreased in BD patients during mania when compared to controls but this difference was no longer significant after treatment, and a sharp increase was found after treatment of the episode of acute mania.

TL;DR: Overall, this study indicates that Nano-N2PY, or other nanoparticles conjugated to metal chelators, may provide a novel therapeutic strategy for AD and other neurodegenerative diseases associated with excess transition metals.

TL;DR: The current results indicate that the reversal of adult neurogenesis could be one of the mechanisms involved in the amelioration of stress-induced deficits.

TL;DR: It is shown that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans, and this is the first study to demonstrate an inverse relationship between a physiological estimate of Cardiac Respiratory Fitness and BDNF.

TL;DR: This letter shows a computer-aided diagnosis technique for the early detection of the Alzheimer's disease (AD) based on single photon emission computed tomography (SPECT) image feature selection and a statistical learning theory classifier that outperformed recent developed methods for early AD diagnosis.

TL;DR: Results indicate that sulforaphane treatment improves performance in the Morris water maze task and reduces working memory dysfunction and reducesWorking memory dysfunction when the treatment was initiated 1h, but not 6h, post-injury.

TL;DR: The sMRI and DT-MRI results indicate that both the GMD and WMI of pianists may exhibit movement-related increases during adolescence or even early adulthood compared with non-musicians.