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Yasushi Isojima
Researcher at Osaka University
Publications - 24
Citations - 1184
Yasushi Isojima is an academic researcher from Osaka University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 15, co-authored 24 publications receiving 1102 citations.
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Journal ArticleDOI
CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock
Yasushi Isojima,Masato Nakajima,Hideki Ukai,Hiroshi Fujishima,Rikuhiro G. Yamada,Koh-hei Masumoto,Reiko Kiuchi,Mayumi Ishida,Maki Ukai-Tadenuma,Yoichi Minami,Ryotaku Kito,Kazuki Nakao,Wataru Kishimoto,Seung Hee Yoo,Seung Hee Yoo,Kazuhiro Shimomura,Toshifumi Takao,Atsuko Takano,Toshio Kojima,Katsuya Nagai,Yoshiyuki Sakaki,Joseph S. Takahashi,Joseph S. Takahashi,Hiroki R. Ueda +23 more
TL;DR: The degradation rate of PER2, which is regulated by CKIε/δ-dependent phosphorylation, was temperature-insensitive in living clock cells, yet sensitive to chemical perturbations, revealing its high sensitivity tochemical perturbation.
Journal ArticleDOI
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock.
Teruya Tamaru,Jun Hirayama,Jun Hirayama,Yasushi Isojima,Katsuya Nagai,Shigemi Norioka,Ken Takamatsu,Paolo Sassone-Corsi +7 more
TL;DR: It is demonstrated that Casein kinase (CK)-2α phosphorylates the core circadian regulator BMAL1, revealing that CK2 is an essential regulator of the mammalian circadian system.
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A missense variation in human Casein kinase I Epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders
Atsuko Takano,Makoto Uchiyama,Naofumi Kajimura,Kazuo Mishima,Yuichi Inoue,Yuichi Kamei,Tsuyoshi Kitajima,Kayo Shibui,Masaaki Katoh,Tsuyoshi Watanabe,Yuki Hashimotodani,Toru Nakajima,Yuji Ozeki,Toru Hori,Naoto Yamada,Ryoichi Toyoshima,Norio Ozaki,Masako Okawa,Katsuya Nagai,Kiyohisa Takahashi,Yasushi Isojima,Toshio Yamauchi,Takashi Ebisawa +22 more
TL;DR: Results indicate that the N408 allele in CKIɛ plays a protective role in the development of DSPS and N-24 through alteration of the enzyme activity.
Journal ArticleDOI
Ultraweak biochemiluminescence detected from rat hippocampal slices.
TL;DR: It was shown that depolarization induced by the high concentration of potassium caused an increase in the intensity of biochemiluminescence from the rat hippocampal slice, and that suppression of neural activity by tetrodotoxin elicited a decrease of its luminescence.
Journal ArticleDOI
Identification of mPer1 phosphorylation sites responsible for the nuclear entry.
TL;DR: It is found that phosphorylation of residues within a region defined by amino acids 653–663 and in particular of Ser-661 and Ser-663, may influence the nuclear translocation of a clock protein complex containing mPer1.