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Yasushi Shintani
Researcher at Takeda Pharmaceutical Company
Publications - 94
Citations - 5641
Yasushi Shintani is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 25, co-authored 94 publications receiving 5266 citations. Previous affiliations of Yasushi Shintani include Japanese Ministry of International Trade and Industry.
Papers
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Journal ArticleDOI
Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta☆
Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Masahiko Hattori,Atsushi Nishimura,Tetsuya Ohtaki,Yasushi Shintani +6 more
TL;DR: The results suggest that metastin/OT7T175 signaling may participate in implantation of the mammalian embryo, placenta formation, and maintenance of pregnancy.
Journal ArticleDOI
A New Peptidic Ligand and Its Receptor Regulating Adrenal Function in Rats
Shoji Fukusumi,Hiromi Yoshida,Ryo Fujii,Minoru Maruyama,Hidetoshi Komatsu,Yugo Habata,Yasushi Shintani,Shuji Hinuma,Masahiko Fujino +8 more
TL;DR: Tissue distributions of QRFP and its receptor mRNAs in rats utilizing quantitative reverse transcription-polymerase chain reaction and in situ hybridization were analyzed and it was found that QRFP mRNA was highly expressed in the hypothalamus, whereas its receptor mRNA was high in the adrenal gland.
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Characteristics and distribution of endogenous RFamide-related peptide-1
Shoji Fukusumi,Yugo Habata,Hiromi Yoshida,Norio Iijima,Yuji Kawamata,Masaki Hosoya,Ryo Fujii,Shuji Hinuma,Chieko Kitada,Yasushi Shintani,Masato Suenaga,Haruo Onda,Osamu Nishimura,Masaki Tanaka,Yasuhiko Ibata,Masahiko Fujino +15 more
TL;DR: In culture, RFRP-1 lowered cAMP production in Chinese hamster ovary cells expressing OT7T022 and it was abolished by pre-treatment with pertussis toxin, suggesting that OT 7T022 couples G(i)/G(o) in the signal transduction pathway.
Patent
Novel g protein-coupled receptor protein and dna thereof
TL;DR: A human-origin protein or its salt can be used in determining a ligand to this protein; preventives and/or remedies for diseases in association with the dysfunction of the above protein; screening compounds (agonists, antagonists, etc.) capable of altering binding properties of the ligand as discussed by the authors.
Journal ArticleDOI
Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.
Masaaki Mori,Mioko Harada,Yasuko Terao,Tsukasa Sugo,Takuya Watanabe,Yukio Shimomura,Michiko Abe,Yasushi Shintani,Haruo Onda,Osamu Nishimura,Masahiko Fujino +10 more
TL;DR: Quantitative polymerase chain reaction analysis of theSLT gene expression in human tissues showed that the SLT receptor is expressed mainly in brain areas including the cerebral cortex, amygdala, hippocampus, and corpus callosum, as well as in a limited number of peripheral tissues.