K
Kavya Swaminathan
Researcher at Stanford University
Publications - 22
Citations - 850
Kavya Swaminathan is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Neuraminidase. The author has an hindex of 10, co-authored 16 publications receiving 687 citations. Previous affiliations of Kavya Swaminathan include Indian Institute of Technology Madras & University of Sydney.
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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
Caleb D. Marceau,Andreas S. Puschnik,Karim Majzoub,Yaw Shin Ooi,Susan M. Brewer,Gabriele Fuchs,Kavya Swaminathan,Miguel A. Mata,Joshua E. Elias,Peter Sarnow,Jan E. Carette +10 more
TL;DR: A pooled CRISPR genetic screening strategy is used to comprehensively dissect host factors required for dengue virus and Hepatitis C virus, and finds an unexpected link between intracellular flavin adenine dinucleotide levels and HCV replication.
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Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens
Michael S. Khodadoust,Niclas Olsson,Lisa E. Wagar,Ole Audun Werner Haabeth,Binbin Chen,Kavya Swaminathan,Keith Rawson,Chih Long Liu,David F. Steiner,Peder Lund,Samhita Rao,Lichao Zhang,Caleb D. Marceau,Henning Stehr,Aaron M. Newman,Debra K. Czerwinski,Victoria Carlton,Martin Moorhead,Malek Faham,Holbrook E Kohrt,Jan E. Carette,Michael R. Green,Mark M. Davis,Ronald Levy,Joshua E. Elias,Ash A. Alizadeh +25 more
TL;DR: This work discovers neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules.
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TagGraph reveals vast protein modification landscapes from large tandem mass spectrometry datasets.
Arun Devabhaktuni,Sarah Lin,Lichao Zhang,Kavya Swaminathan,Carlos Gonzalez,Niclas Olsson,Samuel M. Pearlman,Keith Rawson,Joshua E. Elias +8 more
TL;DR: TagGraph is described, a computational tool that overcomes both challenges with an unrestricted string-based search method that is as much as 350-fold faster than existing approaches, and a probabilistic validation model that is optimized for PTM assignments.
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Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry.
Kavya Swaminathan,Jeffrey Clifford Dyason,Andrea Maggioni,Mark von Itzstein,Kevin M. Downard +4 more
TL;DR: The anthocyanin is shown by parallel experimental and computational approaches to bind in the so-called 430-cavity in the vicinity of neuraminidase residues 356–364 and 395–432, providing the potential for the development of a new class of antivirals against the influenza virus without this susceptibility.
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Inhibition of influenza hemagglutinin with the antiviral inhibitor arbidol using a proteomics based approach and mass spectrometry.
TL;DR: The combined studies support the recognized potential of arbidol as an effective and targeted antiviral agent against the influenza virus.