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Yerong Hu
Researcher at Central South University
Publications - 9
Citations - 2837
Yerong Hu is an academic researcher from Central South University. The author has contributed to research in topics: Receptor tyrosine kinase & Anaplastic lymphoma kinase. The author has an hindex of 5, co-authored 8 publications receiving 2633 citations.
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Journal ArticleDOI
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Klarisa Rikova,Ailan Guo,Qingfu Zeng,Anthony Possemato,Jian Yu,Herbert Haack,Julie Nardone,Kimberly Lee,Cynthia Reeves,Yu Li,Yerong Hu,Zhi-Ping Tan,Matthew P. Stokes,Laura Sullivan,Jeffrey Mitchell,Randy Wetzel,Joan MacNeill,Jian Min Ren,Jin Yuan,Corey E. Bakalarski,Judit Villén,Jon M. Kornhauser,Bradley L. Smith,Daiqiang Li,Xinmin Zhou,Steven P. Gygi,Ting-Lei Gu,Roberto D. Polakiewicz,John Rush,Michael J. Comb +29 more
TL;DR: By focusing on activated cell circuitry, the approach outlined here provides insight into cancer biology not available at the chromosomal and transcriptional levels and can be applied broadly across all human cancers.
Journal ArticleDOI
Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma
Ting-Lei Gu,Xiaxing Deng,Feizhou Huang,Meghan Ann Tucker,Katherine Crosby,Victoria Rimkunas,Yi Wang,Gang Deng,Lei Zhu,Zhi-Ping Tan,Yerong Hu,Chun-Lin Wu,Julie Nardone,Joan MacNeill,Jianmin Ren,Cynthia Reeves,Gregory Innocenti,Brett Norris,Jin Yuan,Jian Yu,Herbert Haack,Baiyong Shen,Chenghong Peng,Hongwei Li,Xinmin Zhou,Xunyang Liu,John Rush,Michael J. Comb +27 more
TL;DR: It is demonstrated that ROS kinase is a promising candidate for a therapeutic target and for a diagnostic molecular marker in cholangiocarcinoma and suggests that a more broadly based screen for activated ROS kinases in cancer is warranted.
Journal ArticleDOI
Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
Victoria Rimkunas,Katherine Crosby,Daiqiang Li,Yerong Hu,Meghan E. Kelly,Ting-Lei Gu,Jennifer S. Mack,Matthew Ren Silver,Xinmin Zhou,Herbert Haack +9 more
TL;DR: The ROS1 IHC assay described here is a valuable tool for identifying patients expressing mutant ROS1 and could be routinely applied in clinical practice to detect lung cancers that may be responsive to targeted therapies.
Journal ArticleDOI
Development of an acellular tumor extracellular matrix as a three-dimensional scaffold for tumor engineering.
TL;DR: Evidence is provided that Tris-Trypsin-Triton treated acellular tumor extracellular matrices are promising 3D scaffolds with ideal spatial arrangement, biomechanical properties and biocompatibility for improved modeling of 3D tumor microenvironments.
Journal ArticleDOI
Photooxidatively crosslinked acellular tumor extracellular matrices as potential tumor engineering scaffolds.
Wei-Dong Lü,Ruifang Sun,Yerong Hu,Jan-Rong Lu,Lu Gu,Zhigang Liu,Guangyan Lei,Zhun Qiang,Lin Cai +8 more
TL;DR: This is the first study to evaluate the feasibility of photooxidatively crosslinked acellular tumor ECMs as 3D scaffolds for cancer research and the results are encouraging.