Yifang Chen

TL;DR: Findings show that KCs are an important source of IFN-β and MAVS is critical to this function, and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions.

TL;DR: The results demonstrate that progenitor function is maintained by DDX6 complexes through two distinct pathways that include the degradation of differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs.

TL;DR: The expression of several subunits of the exosome were found to be enriched in epidermal progenitor cells, which were required to retain proliferative capacity and to prevent premature differentiation.

TL;DR: The levels of SNAI2 binding to genomic targets determine the differentiation status of epithelial cells with increased levels triggering EMT and dedifferentiation, moderate (physiological) levels promoting epidermal progenitor function, and low levels leading toEpidermal differentiation.

TL;DR: In this article, the combination of p63, a master regulator of epidermal development and differentiation, and KLF4, a regulator of dermal differentiation, is sufficient to convert dermal fibroblasts to a keratinocyte phenotype, and the robustness of the conversion process also allows the use of this as a model system to study the mechanisms of reprogramming.