Y
Yilong Yang
Researcher at Academy of Military Medical Sciences
Publications - 18
Citations - 1530
Yilong Yang is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Staphylococcus aureus & Medicine. The author has an hindex of 6, co-authored 12 publications receiving 935 citations.
Papers
More filters
Journal ArticleDOI
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: The epitope of 4A8 is defined as the N-terminal domain (NTD) of the S protein by determining with cryo–eletron microscopy its structure in complex with the Sprotein, which points to the NTD as a promising target for therapeutic mAbs against COVID-19.
Journal ArticleDOI
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.
Shipo Wu,Gongxun Zhong,Jun Zhang,Lei Shuai,Zhe Zhang,Zhiyuan Wen,Busen Wang,Zhao Zhenghao,Xiaohong Song,Chen Yi,Renqiang Liu,Ling Fu,Jie Zhang,Qiang Guo,Chong Wang,Yilong Yang,Fang Ting,Peng Lv,Jinliang Wang,Junjie Xu,Jianmin Li,Changming Yu,Lihua Hou,Zhigao Bu,Wei Chen +24 more
TL;DR: It is found that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted Sars-Co V-2 infection in the upper and lower respiratory tracts.
Posted ContentDOI
A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: A new vulnerable epitope of the S protein is discovered and promising neutralizing mAbs are identified as potential clinical therapy for COVID-19, the pandemic of coronavirus disease 2019.
Journal ArticleDOI
Monoclonal Antibody Targeting Staphylococcus aureus Surface Protein A (SasA) Protect Against Staphylococcus aureus Sepsis and Peritonitis in Mice.
Yilong Yang,Mengying Qian,Shaoqiong Yi,Shuling Liu,Bing Li,Rui Yu,Guo Qiang,Xiaopeng Zhang,Changming Yu,Jianmin Li,Junjie Xu,Wei Chen +11 more
TL;DR: Supporting evidences are provided that an anti-SasA mAb might be a potential component in an antibody-based immunotherapeutic treatment of MRSA infections.
Journal ArticleDOI
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia
Luming Wan,Qi Gao,Yong-Qiang Deng,Yuehua Ke,Enhao Ma,Huan Yang,Haotian Lin,Huilong Li,Yilong Yang,Jing Gong,Jingfei Li,Yixin Xu,Jing Liu,Jianmin Li,Jialong Liu,Xuemin Zhang,Linfei Huang,Jiangyue Feng,Yanhong Zhang,Han-Yu Huang,Huapeng Wang,Changjun Wang,Qi Chen,Xing-Yao Huang,Qing Ye,Dongyu Li,Qiulin Yan,Muyi Liu,Meng Wei,Yun Mo,Dongrui Li,Ke Tang,Changqing Lin,Fei Zheng,Lei Xu,Gong Cheng,Peihui Wang,Xiaopan Yang,Fei-Yue Wu,Zhiwei Sun,Chengfeng Qin,Cong Wen Wei,Hui Zhong +42 more
TL;DR: In this article , the authors connect the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection, and demonstrate that GP73 secretion is induced in multiple tissues upon fasting.