X
Xiaohong Song
Researcher at Academy of Military Medical Sciences
Publications - 24
Citations - 1818
Xiaohong Song is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Epitope & Vaccination. The author has an hindex of 11, co-authored 20 publications receiving 1100 citations.
Papers
More filters
Journal ArticleDOI
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: The epitope of 4A8 is defined as the N-terminal domain (NTD) of the S protein by determining with cryo–eletron microscopy its structure in complex with the Sprotein, which points to the NTD as a promising target for therapeutic mAbs against COVID-19.
Journal ArticleDOI
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.
Shipo Wu,Gongxun Zhong,Jun Zhang,Lei Shuai,Zhe Zhang,Zhiyuan Wen,Busen Wang,Zhao Zhenghao,Xiaohong Song,Chen Yi,Renqiang Liu,Ling Fu,Jie Zhang,Qiang Guo,Chong Wang,Yilong Yang,Fang Ting,Peng Lv,Jinliang Wang,Junjie Xu,Jianmin Li,Changming Yu,Lihua Hou,Zhigao Bu,Wei Chen +24 more
TL;DR: It is found that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted Sars-Co V-2 infection in the upper and lower respiratory tracts.
Journal ArticleDOI
Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial.
Shipo Wu,Jianying Huang,Zhe Zhang,Jianyuan Wu,Jinlong Zhang,Hanning Hu,Tao Zhu,Jun Zhang,Lin Luo,Pengfei Fan,Busen Wang,Chang Chen,Chen Yi,Xiaohong Song,Yudong Wang,Weixue Si,Tianjian Sun,Xinghuan Wang,Lihua Hou,Wei Chen +19 more
TL;DR: In this article, the safety and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults without COVID19 from China was evaluated.
Posted ContentDOI
A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: A new vulnerable epitope of the S protein is discovered and promising neutralizing mAbs are identified as potential clinical therapy for COVID-19, the pandemic of coronavirus disease 2019.
Journal ArticleDOI
Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models.
Qiang Guo,Jasper Fuk-Woo Chan,Vincent Kwok-Man Poon,Shipo Wu,Chris Chung-Sing Chan,Lihua Hou,Cyril C. Y. Yip,Changpeng Ren,Jian-Piao Cai,Mengsu Zhao,Anna Jinxia Zhang,Xiaohong Song,Kwok-Hung Chan,Busen Wang,Kin-Hang Kok,Wen Yanbo,Kwok-Yung Yuen,Wei Chen +17 more
TL;DR: Ad5-Sig-prM-Env provided sterilizing protection against ZIKV infection in mice, and the close correlation between the neutralizing antibody titer and viral load helped to explain the better protective effect of Ad5- Sig- prM-env than Ad5 -Env.