L
Ling Fu
Researcher at Academy of Military Medical Sciences
Publications - 35
Citations - 2469
Ling Fu is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Escherichia coli & Cell culture. The author has an hindex of 11, co-authored 33 publications receiving 1799 citations.
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Journal ArticleDOI
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: The epitope of 4A8 is defined as the N-terminal domain (NTD) of the S protein by determining with cryo–eletron microscopy its structure in complex with the Sprotein, which points to the NTD as a promising target for therapeutic mAbs against COVID-19.
Posted ContentDOI
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
Ke Wang,Wei Chen,Yu-Sen Zhou,Jian-Qi Lian,Zheng Zhang,Peng Du,Li Gong,Yang Zhang,Hong-Yong Cui,Jie-Jie Geng,Bin Wang,Xiu-Xuan Sun,Chun-Fu Wang,Xu Yang,Peng Lin,Yong-Qiang Deng,Ding Wei,Xiang-Min Yang,Yu-Meng Zhu,Kui Zhang,Zhaohui Zheng,Jinlin Miao,Ting Guo,Ying Shi,Jun Zhang,Ling Fu,Qing-Yi Wang,Huijie Bian,Ping Zhu,Zhi-Nan Chen +29 more
TL;DR: The discovery of the new route CD147-SP for SARS-CoV-2 invading host cells provides a critical target for development of specific antiviral drugs.
Journal ArticleDOI
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.
Shipo Wu,Gongxun Zhong,Jun Zhang,Lei Shuai,Zhe Zhang,Zhiyuan Wen,Busen Wang,Zhao Zhenghao,Xiaohong Song,Chen Yi,Renqiang Liu,Ling Fu,Jie Zhang,Qiang Guo,Chong Wang,Yilong Yang,Fang Ting,Peng Lv,Jinliang Wang,Junjie Xu,Jianmin Li,Changming Yu,Lihua Hou,Zhigao Bu,Wei Chen +24 more
TL;DR: It is found that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted Sars-Co V-2 infection in the upper and lower respiratory tracts.
Journal ArticleDOI
Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference.
Yuanjiang Zhang,Tieshi Li,Ling Fu,Changming Yu,Yinghua Li,Xialian Xu,Yinyin Wang,Hongxiu Ning,Shuping Zhang,Wei Chen,Lorne A. Babiuk,Zhijie Chang +11 more
TL;DR: It is demonstrated that the siRNAs could effectively and specifically inhibit gene expression of Spike protein in SARS‐CoV‐infected cells and provided evidence that RNAi could be a tool for inhibition of SARS-CoV.
Journal ArticleDOI
B-Cell Responses in Patients Who Have Recovered from Severe Acute Respiratory Syndrome Target a Dominant Site in the S2 Domain of the Surface Spike Glycoprotein
Xiaofen Zhong,Huanghao Yang,Zu Feng Guo,Wan Yee Fion Sin,Wei Chen,Junjie Xu,Ling Fu,Jie Wu,Chun Kit Gannon Mak,Chak Sum Samuel Cheng,Yanzhen Yang,Shuyong Cao,Tin Yau Wong,Sik To Lai,Yong Xie,Zhihong Guo +15 more
TL;DR: The results suggest that the SARS coronavirus might have an antigenic profile distinct from those of other human or animal coronaviruses, which may enable the design of an epitope-based vaccine to prevent potential antibody-mediated immunuopathology.