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Dong Yunzhu
Researcher at Academy of Military Medical Sciences
Publications - 11
Citations - 1281
Dong Yunzhu is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 5, co-authored 11 publications receiving 839 citations.
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Journal ArticleDOI
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: The epitope of 4A8 is defined as the N-terminal domain (NTD) of the S protein by determining with cryo–eletron microscopy its structure in complex with the Sprotein, which points to the NTD as a promising target for therapeutic mAbs against COVID-19.
Posted ContentDOI
A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: A new vulnerable epitope of the S protein is discovered and promising neutralizing mAbs are identified as potential clinical therapy for COVID-19, the pandemic of coronavirus disease 2019.
Journal ArticleDOI
Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line.
Xinghui Zhao,Zhanzhong Zhao,Junwei Guo,Peitang Huang,Xu-Dong Zhu,Xiaowei Zhou,Zhixin Yang,Lixia Zhao,Long Xu,Junjie Xu,Ling Fu,Zhang Jun,Xiaopeng Zhang,Dong Yunzhu,Gang Huang,Qianfei Wang,Bo Li,Xiaohong Song,Xiuxu Yang,Shuling Liu,Shaoqiong Yi,Ting Yu,Changming Yu,Lihua Hou,Jianmin Li,Wei Chen +25 more
TL;DR: The targeted downregulation of integrated HBx was transcriptionally downregulated using an artificial transcription factor designed to downregulate HBx integrated into the Hep3B HCC cell line.
Posted ContentDOI
Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients
Xiaoying Fan,Chi Xiangyang,Wenji Ma,Suijuan Zhong,Dong Yunzhu,Wei Zhou,Wenyu Ding,Hongyan Fan,Chonghai Yin,Zhentao Zuo,Yilong Yang,Mengyao Zhang,Qiang Ma,Jianwei Liu,Fang Ting,Qian Wu,Wei Chen,Xiaoqun Wang +17 more
TL;DR: Although the T lymphocytes were decreased in the blood of patients with virus infection, the remaining T cells still highly expressed inflammatory genes and persisted for a while after recovery in patients, providing crucial insights into the immune response against patients with severe COVID-19 and recovered patients.
Journal ArticleDOI
Intracellular delivery of artificial transcription factors fused to the protein transduction domain of HIV-1 Tat.
Xinghui Zhao,Dong Yunzhu,Zhanzhong Zhao,Junwei Guo,Jie Liu,Huang Peitang,Dayong Dong,Hongyan Fan,Qiang Guo,Xiuxu Yang,Junjie Xu,Jian-min Li,Ling Fu,Wei Chen +13 more
TL;DR: Tat-ATF-S, which contains the zinc fingers that bind to the SV40 promoter with high specificity, exhibited the desired transcriptional repression activity to the reported genes, indicating the successful cellular delivery and desired conformation of TAT-ATf-S.