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Ying Q. Chen
Researcher at Fred Hutchinson Cancer Research Center
Publications - 37
Citations - 8199
Ying Q. Chen is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: HPTN 052 & Viral load. The author has an hindex of 14, co-authored 34 publications receiving 7363 citations. Previous affiliations of Ying Q. Chen include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Leslie Cottle,Xinyi C. Zhang,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Sharlaa Faesen,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Sarah E. Hudelson,Andrew D. Redd,Thomas R. Fleming +35 more
TL;DR: The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.
Journal ArticleDOI
Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
Beatriz Grinsztejn,Mina C. Hosseinipour,Heather J. Ribaudo,Susan Swindells,Joseph J. Eron,Ying Q. Chen,Lei Wang,San San Ou,Maija Anderson,Marybeth McCauley,Theresa Gamble,N. Kumarasamy,James Hakim,Johnstone Kumwenda,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Marineide Gonçalves de Melo,Kenneth H. Mayer,Susan H. Eshleman,Estelle Piwowar-Manning,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Ian Sanne,Joel E. Gallant,Irving F. Hoffman,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Diane V. Havlir,Myron S. Cohen +32 more
TL;DR: The clinical benefits recorded, combined with the striking reduction in HIV-1 transmission risk previously reported, provides strong support for earlier initiation of antiretroviral treatment.
Journal ArticleDOI
Analysis of Genetic Linkage of HIV From Couples Enrolled in the HIV Prevention Trials Network 052 Trial
Susan H. Eshleman,Sarah E. Hudelson,Andrew D. Redd,Lei Wang,R. Debes,Ying Q. Chen,Craig Martens,Stacy M. Ricklefs,Ethan J. Selig,Stephen F. Porcella,Supriya Munshaw,Stuart C. Ray,Estelle Piwowar-Manning,Marybeth McCauley,Mina C. Hosseinipour,Johnstone Kumwenda,James Hakim,Suwat Chariyalertsak,Guy de Bruyn,Beatriz Grinsztejn,Nagalingeswaran Kumarasamy,Joseph Makhema,Kenneth H. Mayer,José Henrique Pilotto,Breno Santos,Thomas C. Quinn,Thomas C. Quinn,Myron S. Cohen,James P. Hughes,James P. Hughes +29 more
TL;DR: The association of early ART and reduced HIV transmission was stronger when the analysis included only linked events, and underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prevention studies involving serodiscordant couples.
Journal ArticleDOI
Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study.
Darrell P. Wheeler,Sheldon D. Fields,Geetha Beauchamp,Ying Q. Chen,Lynda Emel,Lisa B. Hightow-Weidman,Christopher Hucks-Ortiz,Irene Kuo,Jonathan Lucas,Manya Magnus,Kenneth H. Mayer,Kenneth H. Mayer,Kenneth H. Mayer,LaRon E. Nelson,LaRon E. Nelson,Craig W. Hendrix,Estelle Piwowar-Manning,Steven Shoptaw,Phaedrea Watkins,C. Chauncey Watson,Leo Wilton,Leo Wilton +21 more
TL;DR: This research reports on the HIV Prevention Trials Network 073 study aimed to examine PrEP initiation, utilization and adherence among Black MSM utilizing the theoretically principled, culturally informed and client‐centered care coordination (C4) model.