C
Craig Martens
Researcher at National Institutes of Health
Publications - 119
Citations - 5551
Craig Martens is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Viral load. The author has an hindex of 32, co-authored 103 publications receiving 3901 citations. Previous affiliations of Craig Martens include Rocky Mountain Laboratories & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.
Victoria A. Avanzato,Victoria A. Avanzato,M. Jeremiah Matson,M. Jeremiah Matson,Stephanie N. Seifert,Rhys Pryce,Brandi N. Williamson,Sarah L. Anzick,Kent D. Barbian,Seth D. Judson,Elizabeth R. Fischer,Craig Martens,Thomas A. Bowden,Emmie de Wit,Francis X. Riedo,Vincent J. Munster +15 more
TL;DR: The data indicate that certain immunocompromised patients may shed infectious virus for longer durations than previously recognized, and detection of subgenomic RNA is recommended in persistently SARS-CoV-2 positive individuals as a proxy for shedding of infectious virus.
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Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Brandi N. Williamson,Friederike Feldmann,Benjamin Schwarz,Kimberly Meade-White,Danielle P. Porter,Jonathan E Schulz,Neeltje van Doremalen,Ian Leighton,Claude Kwe Yinda,Lizzette Pérez-Pérez,Atsushi Okumura,Jamie Lovaglio,Patrick W. Hanley,Greg Saturday,Catharine M. Bosio,Sarah L. Anzick,Kent D. Barbian,Tomas Cihlar,Craig Martens,Dana P. Scott,Vincent J. Munster,Emmie de Wit +21 more
TL;DR: The data support the early initiation of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia and reduce viral load and lung disease in a rhesus macaque model of SARS-CoV-2 infection.
Journal ArticleDOI
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae
Frank R. DeLeo,Liang Chen,Stephen F. Porcella,Craig Martens,Scott D. Kobayashi,Adeline R. Porter,Kalyan D. Chavda,Michael R. Jacobs,Barun Mathema,Randall J. Olsen,Robert A. Bonomo,Robert A. Bonomo,James M. Musser,Barry N. Kreiswirth +13 more
TL;DR: In this paper, the authors found that carbapenem-resistant Klebsiella pneumoniae is a single genetic clone that has disseminated worldwide, which disproved the single-clone hypothesis.
Posted ContentDOI
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Brandi N. Williamson,Friederike Feldmann,Benjamin Schwarz,Kimberly Meade-White,Danielle P. Porter,Jonathan E Schulz,Neeltje van Doremalen,Ian Leighton,Claude Kwe Yinda,Lizzette Pérez-Pérez,Atsushi Okumura,Jamie Lovaglio,Patrick W. Hanley,Greg Saturday,Catharine M. Bosio,Sarah L. Anzick,Kent D. Barbian,Tomas Cihlar,Craig Martens,Dana P. Scott,Vincent J. Munster,Emmie de Wit +21 more
TL;DR: Therapeutic remdesivir treatment initiated early during infection has a clear clinical benefit in SARS-CoV-2-infected rhesus macaques and these data support early remdesavir treatment initiation in COVID-19 patients to prevent progression to severe pneumonia.
Journal ArticleDOI
Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing
TL;DR: Deep RNA sequencing was used to simultaneously analyze vaccinia virus (VACV) and HeLa cell transcriptomes at progressive times following infection, revealing two clusters of early mRNAs that were synthesized in the presence of inhibitors of protein as well as DNA synthesis, indicating that they do not correspond to separate immediate- and delayed-early classes as defined for other DNA viruses.