Ying Tang

TL;DR: It is reported that interaction of neuronal nitric oxide synthase (nNOS) with the protein postsynaptic density-95 (PSD-95) negatively controls regenerative repair after stroke in rats and can serve as a target for regenerative Repair after stroke.

TL;DR: This study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri-infarct neurons as well as augmenting neuroinflammation.

TL;DR: In the rat model of transient cerebral ischemia and reperfusion, the combination of edaravone and borneol significantly ameliorated ischemic damage with an optimal proportion of 4:1 and promoted long-term effect, including improved elemental vital signs, sensorimotor functions and spatial cognition.

TL;DR: Evidence is provided that HDAC2 is a crucial target for functional recovery from stroke via epigenetically enhancing neuroplasticity of surviving neurons in the peri‐infarct zone.

TL;DR: Dissociating N-methyl-D-aspartate receptor–postsynaptic density protein-95 coupling by Tat-HA-NR2B9c in the subacute phase after stroke promotes functional recovery, probably because of that it increases neurogenesis and dendritic spine density of mature neurons via regulating cyclin-dependent kinase 5 in the ischemic brain.