Yu-Hui Lin

TL;DR: In this article, the coupling between neuronal nitric oxide synthase (nNOS) and its carboxy-terminal PDZ ligand (CAPON) can serve as a target for developing new anxiolytic agents.

TL;DR: It is reported that interaction of neuronal nitric oxide synthase (nNOS) with the protein postsynaptic density-95 (PSD-95) negatively controls regenerative repair after stroke in rats and can serve as a target for regenerative Repair after stroke.

TL;DR: This study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri-infarct neurons as well as augmenting neuroinflammation.

TL;DR: It is shown that neural projections from the anterior cingulate cortex to ventral hippocampus control the expression of contextual fear generalization in male mice, indicating that manipulating the circuit may prevent or reverse fear overgeneralization in subjects with PTSD.

TL;DR: It is revealed that nNOS-expressing neurons in ventromedial prefrontal cortex (vmPFC) are essential for pain-induced anxiety but not algesia, using optogenetic and chemogenetic strategies and that excitatory projections from the posterior subregion of paraventricular thalamic nucleus (pPVT) provide a neuronal input that drives the activation of vmPFC nN OS-expressed neurons in chronic pain models.