K
Kevin K. Kim
Researcher at University of Michigan
Publications - 35
Citations - 3605
Kevin K. Kim is an academic researcher from University of Michigan. The author has contributed to research in topics: Fibrosis & Pulmonary fibrosis. The author has an hindex of 22, co-authored 34 publications receiving 3062 citations. Previous affiliations of Kevin K. Kim include University of California, San Francisco & Cardiovascular Institute of the South.
Papers
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Journal ArticleDOI
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Kevin K. Kim,Matthias C. Kugler,Paul J. Wolters,Liliane Robillard,Michael G. Galvez,Alexis N. Brumwell,Dean Sheppard,Harold A. Chapman +7 more
TL;DR: Alveolar epithelial cells are revealed as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
Journal ArticleDOI
Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Kevin K. Kim,Ying Wei,Charles Szekeres,Matthias C. Kugler,Paul J. Wolters,Marla L. Hill,James A. Frank,Alexis N. Brumwell,Sarah E. Wheeler,Jordan A. Kreidberg,Harold A. Chapman +10 more
TL;DR: Findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis.
Journal ArticleDOI
TGF-β1 Signaling and Tissue Fibrosis.
TL;DR: The current understanding of the core functions of TGF-β1 in promoting collagen accumulation, parallel pathways that promote physiological repair, and pathological triggers that tip the balance toward progressive fibrosis are examined.
Journal ArticleDOI
Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts
Young Sam Kim,Matthias C. Kugler,Ying Wei,Kevin K. Kim,Xiaopeng Li,Alexis N. Brumwell,Harold A. Chapman +6 more
TL;DR: It is demonstrated that α3β1 coordinates cross talk between β-catenin and Smad signaling pathways as a function of extracellular contact cues and thereby regulates responses to TGF-β1 activation.
Journal ArticleDOI
Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis
Cecilia Marmai,Rachel E. Sutherland,Kevin K. Kim,Gregory Dolganov,Xiaohui Fang,Sophia S. Kim,Shuwei Jiang,J.A. Golden,Charles W. Hoopes,Michael A. Matthay,Harold A. Chapman,Paul J. Wolters +11 more
TL;DR: It is suggested that alveolar type II cells can acquire features of mesenchymal cells in IPF lungs and that TGF-β can mediate this process.