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Yingqiu Xie
Researcher at Nazarbayev University
Publications - 77
Citations - 2305
Yingqiu Xie is an academic researcher from Nazarbayev University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 23, co-authored 60 publications receiving 1818 citations. Previous affiliations of Yingqiu Xie include University at Albany, SUNY & University of Maryland, Baltimore.
Papers
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Journal ArticleDOI
Regulation of androgen receptor activity by tyrosine phosphorylation
Zhiyong Guo,Bojie Dai,Tianyun Jiang,Kexin Xu,Yingqiu Xie,Oekyung Kim,Issa Nesheiwat,Xiangtian Kong,Jonathan Melamed,Venkatesh D. Handratta,Vincent C. O. Njar,Angela Brodie,Li Rong Yu,Timothy D. Veenstra,Hegang Chen,Yun Qiu +15 more
TL;DR: It is reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors and such modification may be important for prostate tumor growth under androgen-depleted conditions.
Journal ArticleDOI
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Yingqiu Xie,Kexin Xu,Douglas E. Linn,Xi Yang,Zhiyong Guo,Hermela Shimelis,Takeo Nakanishi,Douglas D. Ross,Hegang Chen,Ladan Fazli,Martin E. Gleave,Yun Qiu +11 more
TL;DR: The data suggest that Pim-1L may protect prostate cancer cells from apoptosis, at least in part, through regulation of transmembrane drug efflux pump, and may provide a potential therapeutic approach by disrupting PIM-1 signaling to reverse BCRP-mediated multidrug resistance.
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The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.
TL;DR: The results suggest that these two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa PIM-1 may play a more prominent role in drug resistance in prostate cancer cells.
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A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells
Douglas E. Linn,Xi Yang,Feng Sun,Yingqiu Xie,Hege Chen,Richeng Jiang,Hegang Chen,Saranya Chumsri,Angelika M. Burger,Yun Qiu +9 more
TL;DR: The data suggest that OCT4 re-expression in cancer cells may play an important role in carcinogenesis and provide one possible mechanism by which cancer cells acquire/maintain a drug-resistant phenotype.
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Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: Viral and cancer signaling mechanisms.
TL;DR: Chemical compound-target-pathway network data suggest that potential compounds in Rhizoma Polygonati may act on different targets and have a great potential in treatment of COVID-19.