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Tianyun Jiang
Researcher at University of Maryland, Baltimore
Publications - 6
Citations - 782
Tianyun Jiang is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Tyrosine phosphorylation & Tyrosine kinase. The author has an hindex of 5, co-authored 6 publications receiving 733 citations.
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Journal ArticleDOI
Regulation of androgen receptor activity by tyrosine phosphorylation
Zhiyong Guo,Bojie Dai,Tianyun Jiang,Kexin Xu,Yingqiu Xie,Oekyung Kim,Issa Nesheiwat,Xiangtian Kong,Jonathan Melamed,Venkatesh D. Handratta,Vincent C. O. Njar,Angela Brodie,Li Rong Yu,Timothy D. Veenstra,Hegang Chen,Yun Qiu +15 more
TL;DR: It is reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors and such modification may be important for prostate tumor growth under androgen-depleted conditions.
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Interaction between Src and a C-terminal Proline-rich Motif of Akt Is Required for Akt Activation
Tianyun Jiang,Yun Qiu +1 more
TL;DR: Evidence is provided that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt, and it is noteworthy that this PXXP motif is conserved throughout several members of AGC kinase family.
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The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.
TL;DR: The results suggest that these two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa PIM-1 may play a more prominent role in drug resistance in prostate cancer cells.
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Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells
TL;DR: The data suggest a synergism of Ser/Thr kinase Pim1 and tyrosine kinase Etk in IL6 signaling and provide new insights into ligand-independent activation of androgen receptor in prostate cancer cells.
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Bi-directional Regulation between Tyrosine Kinase Etk/BMX and Tumor Suppressor p53 in Response to DNA Damage
TL;DR: It is proposed that the stoichiometry between p53 and the Tec family kinases in a given cell type may determine its sensitivity to chemotherapeutic drugs.