Yiqing Lu

TL;DR: In this paper, a tunable luminescence lifetime τ in the microsecond region can be exploited to code individual upconversion nanocrystals, which can be used for multichannel bioimaging, high-throughput cytometry quantification, and high-density data storage.

TL;DR: These engineered nanocrystals offer saturation intensity two orders of magnitude lower than those of fluorescent probes currently employed in stimulated emission depletion microscopy, suggesting a new way of alleviating the square-root law that typically limits the resolution that can be practically achieved by such techniques.

TL;DR: It is demonstrated that high excitation irradiance can alleviate concentration quenching in upconversion luminescence when combined with higher activator concentration, which can be increased from 0.5 mol% to 8 mol% Tm(3+) in NaYF₄.

TL;DR: Lanthanide-doped NIR-II nanoparticles with engineered luminescence lifetimes are presented with in vivo quantitative imaging using time-domain multiplexing to identify tumour subtypes in living mice and it is demonstrated that robust lifetime coding is independent of tissue penetration depth.

TL;DR: The work addresses some of the major shortcomings in IF-PAMAM and provides a promising application of these probes in the development of drug delivery in the CNS.