Jia Li

TL;DR: The work addresses some of the major shortcomings in IF-PAMAM and provides a promising application of these probes in the development of drug delivery in the CNS.

TL;DR: Glycosylated “triple-interaction” stabilized siRNA nanomedicine ameliorated AD neuropathology by targeting BACE1 and restored the deterioration of cognitive capacity in AD mice without notable side effects, which supports the utility of RNA interference therapy in neurodegenerative diseases.

TL;DR: The experimental results demonstrate that the developed Ang‐NCss(siRNA) displays long circulation in plasma, efficient BBB penetration capability, and GBM accumulation and retention, as well as responsive intracellular siRNA release due to the unique design of small size with polymeric shell for siRNA protection.

TL;DR: A novel technology with "Blockmirs," inhibitors that bind to the miR-27 binding site in VE-cadherin were used, and targeting of endothelial junctional molecules by miRNAs has clinical potential, especially in diseases associated with vascular leak.

TL;DR: The paralogues miR-23a and miB-23b can have profoundly different effects on endothelial cell function due at least partially to selective effects on target proteins and differences in expression patterns of the miRs.