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Yohannes Hagos
Researcher at University of Göttingen
Publications - 60
Citations - 2544
Yohannes Hagos is an academic researcher from University of Göttingen. The author has contributed to research in topics: Organic anion transporter 1 & Organic cation transport proteins. The author has an hindex of 23, co-authored 57 publications receiving 2206 citations.
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Journal ArticleDOI
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
Sara Lovisa,Valerie S. LeBleu,Björn Tampe,Hikaru Sugimoto,Komal Vadnagara,Julienne L. Carstens,Chia Chin Wu,Yohannes Hagos,Birgitta C. Burckhardt,Tsvetelina Pentcheva-Hoang,Hersharan Nischal,James P. Allison,Michael Zeisberg,Raghu Kalluri +13 more
TL;DR: In mouse models of experimentally induced renal fibrosis, conditional deletion of Twist1 or Snai1 in proximal TECs resulted in inhibition of the EMT program and the maintenance of TEC integrity, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of the kidney parenchyma and attenuating interstitial fibrosis.
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Human Renal Organic Anion Transporter 4 Operates as an Asymmetric Urate Transporter
TL;DR: In this article, the authors evaluated the physiologic role, transport mode, and driving forces of human organic anion transporter 4 (hOAT4) and showed that it facilitates substantial uptake of [(14)C]urate, which was elevated 2.6-fold by intracellular HCTZ.
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Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13) *
Andrew Bahn,Yohannes Hagos,Stefan Reuter,Daniela Balen,Hrvoje Brzica,Wolfgang Krick,Birgitta C. Burckhardt,Ivan Sabolić,Gerhard Burckhardt +8 more
TL;DR: Surprisingly, urate–/glutathione exchange by hOAT10 is detected, consistent with an involvement of hO AT10 in the renal glutathione cycle, and the first molecular evidence for cyclosporine A-induced hyperuricemia is provided.
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Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition.
Marija Ljubojević,Carol M. Herak-Kramberger,Yohannes Hagos,Andrew Bahn,Hitoshi Endou,Gerhard Burckhardt,Ivan Sabolić +6 more
TL;DR: Gender differences in the rat renal cortical OAT1 and OAT3 (M > F) appear after puberty and are determined by both a stimulatory effect of androgens (and progesterone in the case of OAT2) and an inhibitory effect of estrogens.
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Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
Andrew Bahn,Marija Ljubojević,Heiko Lorenz,Christian Schultz,Estifanos Ghebremedhin,Bernhard Ugele,Ivan Sabolić,Gerhard Burckhardt,Yohannes Hagos +8 more
TL;DR: Six tryptophan metabolites, including the bioactive substances KYNA, XA, and the serotonin metabolite 5-hydroxyindol acetate inhibited [(3)H]p-aminohippurate (PAH) or 6-carboxyfluorescein (6-CF) uptake by 50-85%, demonstrating that these compounds interact with OAT1 as well as with Oat3.