H
Hikaru Sugimoto
Researcher at University of Texas MD Anderson Cancer Center
Publications - 32
Citations - 11112
Hikaru Sugimoto is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Fibrosis & Cancer. The author has an hindex of 17, co-authored 26 publications receiving 8662 citations. Previous affiliations of Hikaru Sugimoto include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng,Julienne L. Carstens,Jiha Kim,Matthew Scheible,Judith Kaye,Hikaru Sugimoto,Chia Chin Wu,Valerie S. LeBleu,Raghu Kalluri +8 more
TL;DR: This study functionally probes the role of EMT in PDAC by generating mouse models of PDAC with deletion of Snail or Twist, two key transcription factors responsible for EMT, and highlights the importance of combining EMT inhibition with chemotherapy for the treatment of pancreatic cancer.
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Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Sushrut Kamerkar,Valerie S. LeBleu,Hikaru Sugimoto,Sujuan Yang,Carolina F. Ruivo,Sonia A. Melo,Sonia A. Melo,J. Jack Lee,Raghu Kalluri +8 more
TL;DR: The results demonstrate an approach for direct and specific targeting of oncogenic KRAS in tumours using iExosomes, and suppressed cancer in multiple mouse models of pancreatic cancer and significantly increased overall survival.
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Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Sonia A. Melo,Hikaru Sugimoto,Hikaru Sugimoto,Joyce T. O’Connell,Noritoshi Kato,Alberto Villanueva,August Vidal,Le Qiu,Edward Vitkin,Lev T. Perelman,Carlos A. Melo,Anthony Lucci,Cristina Ivan,George A. Calin,Raghu Kalluri,Raghu Kalluri +15 more
TL;DR: It is reported that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor micro RNAs (pre-miRNas) into mature miRNAs.
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Origin and function of myofibroblasts in kidney fibrosis.
Valerie S. LeBleu,Gangadhar Taduri,Joyce T. O’Connell,Yingqi Teng,Vesselina G. Cooke,Craig B. Woda,Hikaru Sugimoto,Hikaru Sugimoto,Raghu Kalluri +8 more
TL;DR: The data suggest that targeting diverse pathways is required to substantially inhibit the composite accumulation of myofibroblasts in kidney fibrosis, and specific deletion of Tgfbr2 in α-smooth muscle actin (αSMA)+ cells revealed the importance of this pathway in the recruitment of my ofibro Blasts through differentiation.