T
Tsvetelina Pentcheva-Hoang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 10
Citations - 4058
Tsvetelina Pentcheva-Hoang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: T cell & Fibrosis. The author has an hindex of 8, co-authored 10 publications receiving 3217 citations. Previous affiliations of Tsvetelina Pentcheva-Hoang include Memorial Sloan Kettering Cancer Center & University of California, Berkeley.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
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Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
Sara Lovisa,Valerie S. LeBleu,Björn Tampe,Hikaru Sugimoto,Komal Vadnagara,Julienne L. Carstens,Chia Chin Wu,Yohannes Hagos,Birgitta C. Burckhardt,Tsvetelina Pentcheva-Hoang,Hersharan Nischal,James P. Allison,Michael Zeisberg,Raghu Kalluri +13 more
TL;DR: In mouse models of experimentally induced renal fibrosis, conditional deletion of Twist1 or Snai1 in proximal TECs resulted in inhibition of the EMT program and the maintenance of TEC integrity, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of the kidney parenchyma and attenuating interstitial fibrosis.
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Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]
Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Raghu Kalluri +20 more
TL;DR: This research highlights the need to understand more fully the role of language in the development of post-traumatic stress disorder and the role that language can play in the recovery.
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B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
TL;DR: It is shown that ligand binding is important for the accumulation of both CD28 and CTLA-4 at the synapse, and that B7-1 is the major ligand mediating CT LA-4 localization, while B 7-2 is the main ligand for CD28 concentration at thesynapse.
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Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections.
TL;DR: The application of findings from basic research has provided insight into the manipulation of these pathways in the clinic and offers promising strategies for the treatment of disease.