Y
Yoichi Maekawa
Researcher at Gifu University
Publications - 85
Citations - 3735
Yoichi Maekawa is an academic researcher from Gifu University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 28, co-authored 82 publications receiving 3435 citations. Previous affiliations of Yoichi Maekawa include University of Tokushima & Kyushu University.
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Journal ArticleDOI
Escape of malaria parasites from host immunity requires CD4(+)CD25(+) regulatory T cells
Hajime Hisaeda,Yoichi Maekawa,Daiji Iwakawa,Hiroko Okada,Kunisuke Himeno,Kenji Kishihara,Shin-ichi Tsukumo,Koji Yasutomo +7 more
TL;DR: This paper showed that depletion of CD4+CD25+ regulatory T cells (T(reg)) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens.
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Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4+ T Cells
Yoichi Maekawa,Shin-ichi Tsukumo,Shigeru Chiba,Hisamaru Hirai,Yuki Hayashi,Hiroko Okada,Kenji Kishihara,Koji Yasutomo +7 more
TL;DR: This work provides direct evidence that the Delta1 interaction with Notch3 on CD4+ T cells transduces signals, promoting development toward the Th1 phenotype and revealing a clear contribution of Notch pathways to Th1 versus Th2 fate decisions, while also providing insight into another mechanism for inhibition of CD4- T cell activation.
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A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans
Akiko Kitamura,Yoichi Maekawa,Hisanori Uehara,Keisuke Izumi,Izumi Kawachi,Masatoyo Nishizawa,Yasuko Toyoshima,Hitoshi Takahashi,Daron M. Standley,Keiji Tanaka,Jun Hamazaki,Shigeo Murata,Koji Obara,Itaru Toyoshima,Koji Yasutomo +14 more
TL;DR: Findings identify PSMB8 as an essential component and regulator not only of inflammation, but also of adipocyte differentiation, and indicate that immunoproteasomes have pleiotropic functions in maintaining the homeostasis of a variety of cell types.
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Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
Yoichi Maekawa,Yoshiaki Minato,Chieko Ishifune,Takeshi Kurihara,Akiko Kitamura,Hidefumi Kojima,Hideo Yagita,Mamiko Sakata-Yanagimoto,Mamiko Sakata-Yanagimoto,Toshiki Saito,Ichiro Taniuchi,Shigeru Chiba,Shigeru Chiba,Saburo Sone,Koji Yasutomo +14 more
TL;DR: The results suggest that the highly regulated, dynamic control of T cell cytotoxicity depends on the integration of Notch2 and CREB1 signals.
Journal ArticleDOI
Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
Muhammad Shamsul Alam,Yoichi Maekawa,Akiko Kitamura,Kenji Tanigaki,Takayuki Yoshimoto,Kenji Kishihara,Koji Yasutomo +6 more
TL;DR: A Notch–AhR axis is identified that regulates IL-22 expression and fine-tunes immune system control of inflammatory responses and protected RBP-J-deficient mice from ConA-induced hepatitis.