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Yolanda D. Mahnke
Researcher at Vaccine Research Center
Publications - 33
Citations - 7077
Yolanda D. Mahnke is an academic researcher from Vaccine Research Center. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 19, co-authored 32 publications receiving 5885 citations. Previous affiliations of Yolanda D. Mahnke include Ludwig Institute for Cancer Research & German Cancer Research Center.
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Journal ArticleDOI
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Shannon L. Maude,Noelle Frey,Pamela A. Shaw,Richard Aplenc,David M. Barrett,Nancy Bunin,Anne Chew,Vanessa E. Gonzalez,Zhaohui Zheng,Simon F. Lacey,Yolanda D. Mahnke,J. Joseph Melenhorst,Susan R. Rheingold,Angela Shen,David T. Teachey,Bruce L. Levine,Carl H. June,David L. Porter,Stephan A. Grupp +18 more
TL;DR: Chimeric antigen receptor-modified T-cell therapy against CD19 was effective in treating relapsed and refractory ALL and was associated with a high remission rate, even among patients for whom stem-cell transplantation had failed, and durable remissions up to 24 months were observed.
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The who's who of T-cell differentiation: human memory T-cell subsets.
TL;DR: Recent developments in the characterization of the heterogeneity of the memory T‐cell compartment are reviewed, and a unified classification of both human and nonhuman primate T cells on the basis of phenotypic traits and in vivo properties is proposed.
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Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma
Alfred L. Garfall,Marcela V. Maus,Wei-Ting Hwang,Simon F. Lacey,Yolanda D. Mahnke,J. Joseph Melenhorst,Zhaohui Zheng,Dan T. Vogl,Adam D. Cohen,Brendan M. Weiss,Karen Dengel,Naseem Kerr,Adam Bagg,Bruce L. Levine,Carl H. June,Edward A. Stadtmauer +15 more
TL;DR: A patient with refractory multiple myeloma received an infusion of CTL019 cells, a cellular therapy consisting of autologous T cells transduced with an anti-CD19 chimeric antigen receptor, after myeloablative chemotherapy and autOLOGous stem-cell transplantation, which led to a complete response.
Journal ArticleDOI
Bone marrow as a priming site for T-cell responses to blood-borne antigen
Markus Feuerer,Philipp Beckhove,Natalio Garbi,Yolanda D. Mahnke,Andreas Limmer,Mirja Hommel,Günter J. Hämmerling,Bruno Kyewski,Alf Hamann,Viktor Umansky,Volker Schirrmacher +10 more
TL;DR: It is demonstrated that naive, antigen-specific T cells home to bone marrow, where they can be primed, and highlighted the uniqueness of bone marrow as an organ important for hemato- and lymphopoiesis and for systemic T cell–mediated immunity.
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The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis
Mario Roederer,Lydia Quaye,Massimo Mangino,Massimo Mangino,Margaret H. Beddall,Yolanda D. Mahnke,Pratip K. Chattopadhyay,Isabella Tosi,Isabella Tosi,Luca Napolitano,Manuela Terranova Barberio,Cristina Menni,Federica Villanova,Federica Villanova,Paola Di Meglio,Tim D. Spector,Frank O. Nestle,Frank O. Nestle +17 more
TL;DR: This data set reveals traits associated with loci known to confer autoimmune susceptibility, providing mechanistic hypotheses linking immune traits with the etiology of disease, and establishes a bioresource that links genetic control elements associated with normal immune traits to common autoimmune and infectious diseases.