M
Margaret H. Beddall
Researcher at National Institutes of Health
Publications - 19
Citations - 1089
Margaret H. Beddall is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 12, co-authored 16 publications receiving 957 citations. Previous affiliations of Margaret H. Beddall include Beth Israel Deaconess Medical Center & Vaccine Research Center.
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Journal ArticleDOI
The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis
Mario Roederer,Lydia Quaye,Massimo Mangino,Massimo Mangino,Margaret H. Beddall,Yolanda D. Mahnke,Pratip K. Chattopadhyay,Isabella Tosi,Isabella Tosi,Luca Napolitano,Manuela Terranova Barberio,Cristina Menni,Federica Villanova,Federica Villanova,Paola Di Meglio,Tim D. Spector,Frank O. Nestle,Frank O. Nestle +17 more
TL;DR: This data set reveals traits associated with loci known to confer autoimmune susceptibility, providing mechanistic hypotheses linking immune traits with the etiology of disease, and establishes a bioresource that links genetic control elements associated with normal immune traits to common autoimmune and infectious diseases.
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Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys
Michael S. Seaman,Ling Xu,Kristin Beaudry,Kristi L. Martin,Margaret H. Beddall,Ayako Miura,Anna Sambor,Bimal K. Chakrabarti,Yue Huang,Robert T. Bailer,Richard A. Koup,John R. Mascola,Gary J. Nabel,Norman L. Letvin,Norman L. Letvin +14 more
TL;DR: It is demonstrated that it is possible to generate protective immune responses by vaccination with genetically diverse isolates of HIV-1 and suggested that a multicomponent vaccine encoding Env proteins from multiple clades of HIV -1 can generate broad Env-specific T-lymphocyte and antibody responses without antigenic interference.
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Human Macrophages Support Persistent Transcription From Unintegrated HIV-1 DNA
Jeremy Kelly,Margaret H. Beddall,Dongyang Yu,Subashini R. Iyer,Jon W. Marsh,Yuntao Wu,Yuntao Wu +6 more
TL;DR: An in vitro examination of HIV infection of macrophages finds that unintegrated viral DNA not only has an unusual stability, but also maintains biological activity and independent of integration, the HIV infection process in macrophage leads to generation of numerous chemokines.
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Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses
Keith A. Reimann,Robert A. Parker,Michael S. Seaman,Kristin Beaudry,Margaret H. Beddall,Lauren Peterson,Kenneth C. Williams,Ronald S. Veazey,David C. Montefiori,John R. Mascola,Gary J. Nabel,Norman L. Letvin +11 more
TL;DR: It is demonstrated that the pathogenicity of nonhuman primate lentiviruses varies markedly based on the species or geographic origin of the macaques infected and suggested that the cellular immune responses may contribute to the control of pathogenicicity in cynomolgus macaques.
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Innate and adaptive immune traits are differentially affected by genetic and environmental factors
TL;DR: Analysis of immune phenotypes in adult female twins highlights the importance of shared childhood environmental influences in shaping immune homeostasis for monocytes, B1 cells, γδ T cells and NKT cells, whereas dendritic cells, B2 cells, CD4+ T and CD8+ T cells are more influenced by genetics.