F
Frank O. Nestle
Researcher at King's College London
Publications - 267
Citations - 33466
Frank O. Nestle is an academic researcher from King's College London. The author has contributed to research in topics: Psoriasis & Immune system. The author has an hindex of 78, co-authored 260 publications receiving 30543 citations. Previous affiliations of Frank O. Nestle include Guy's and St Thomas' NHS Foundation Trust & National Institute for Health Research.
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Journal ArticleDOI
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells.
Frank O. Nestle,Selma Alijagic,Michel Gilliet,Yuansheng Sun,Stephan Grabbe,Reinhard Dummer,Günter Burg,Dirk Schadendorf +7 more
TL;DR: Vaccination with autologous DCs generated from peripheral blood is a safe and promising approach in the treatment of metastatic melanoma and antigen-specific immunity was induced during DC vaccination.
Journal ArticleDOI
Mechanisms of Disease: Psoriasis.
TL;DR: Anti-TNF strategies have three variants: a humanized chimeric anti–TNF- α monoclonal antibody, a fully human monocolonal anti-T NF- α antibody, and a human p75 TNF-receptor Fc fusion protein.
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
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Skin immune sentinels in health and disease
TL;DR: This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease and newly identified CD103+ dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens.
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Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Frank O. Nestle,Curdin Conrad,Adrian Tun-Kyi,Bernhard Homey,Michael Gombert,Onur Boyman,Günter Burg,Yong-Jun Liu,Michel Gilliet +8 more
TL;DR: It is suggested that PDCs and PDC-derived IFN-α represent potential early targets for the treatment of psoriasis and a novel innate immune pathway for triggering a common human autoimmune disease is uncovered.