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Yolande Chvatchko
Researcher at Merck Serono
Publications - 35
Citations - 2853
Yolande Chvatchko is an academic researcher from Merck Serono. The author has contributed to research in topics: Interleukin 18 & Proinflammatory cytokine. The author has an hindex of 21, co-authored 34 publications receiving 2676 citations.
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Journal ArticleDOI
Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability
Ziad Mallat,Anne Corbaz,Alexandra Scoazec,Sandrine Besnard,Guy Lesèche,Yolande Chvatchko,Alain Tedgui +6 more
TL;DR: These results suggest, for the first time, a major role for IL-18 in atherosclerotic plaque destabilization leading to acute ischemic syndromes.
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Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability
Ziad Mallat,Anne Corbaz,Alexandra Scoazec,Pierre Graber,Sami Alouani,Bruno Esposito,Yves Humbert,Yolande Chvatchko,Alain Tedgui +8 more
TL;DR: In vivo electrotransfer of an expression-plasmid DNA encoding for murine IL-18 binding protein (BP) (the endogenous inhibitor of IL- 18) prevents fatty streak development in the thoracic aorta of apoE knockout mice and slows progression of advanced atherosclerotic plaques in the aortic sinus.
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A Key Role for Cc Chemokine Receptor 4 in Lipopolysaccharide-Induced Endotoxic Shock
Yolande Chvatchko,Arlene J. Hoogewerf,Alexandra Meyer,Sami Alouani,Pierre Juillard,Raphaële Buser,Francois Conquet,Amanda E. I. Proudfoot,Timothy N. C. Wells,Christine A. Power +9 more
TL;DR: The data reveal an unexpected role for CCR4 in the inflammatory response leading to LPS-induced lethality, which may reflect a defect in the ability of the CCR 4−/− macrophages to be retained in the peritoneal cavity.
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A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.
Daniela Novick,Boris Schwartsburd,Ron Pinkus,Dan Suissa,Ilana Belzer,Zev Sthoeger,William F. Keane,Yolande Chvatchko,Soohyun Kim,Giamila Fantuzzi,Charles A. Dinarello,Menachem Rubinstein +11 more
TL;DR: It is concluded that IL-18BPa considerably inhibits circulatingIL-18 in sepsis, yet, exogenous administration of IL- 18BPa may further reduce circulating IL-16 activity.
Journal ArticleDOI
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
Christine Plater-Zyberk,Leo A. B. Joosten,Monique M. Helsen,Pascale Sattonnet-Roche,Christiane Siegfried,Sami Alouani,Fons A. J. van de Loo,Pierre Graber,Shuki Aloni,Rocco Cirillo,Erik Lubberts,Charles A. Dinarello,Wim B. van den Berg,Yolande Chvatchko +13 more
TL;DR: It is demonstrated that neutralizing endogenous IL-18 is therapeutically efficacious in the murine model of collagen-induced arthritis and could represent new disease-modifying anti-rheumatic drugs that warrant testing in clinical trials in patients with rheumatoid arthritis.