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Alain Tedgui
Researcher at University of Paris
Publications - 333
Citations - 36718
Alain Tedgui is an academic researcher from University of Paris. The author has contributed to research in topics: Inflammation & Endothelium. The author has an hindex of 98, co-authored 325 publications receiving 34281 citations. Previous affiliations of Alain Tedgui include Lille University of Science and Technology & Paris Descartes University.
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Journal ArticleDOI
Cytokines in atherosclerosis: pathogenic and regulatory pathways.
Alain Tedgui,Ziad Mallat +1 more
TL;DR: Based on the current knowledge of the role of cytokines in atherosclerosis, some novel therapeutic strategies to combat this disease are proposed and the potential of circulating cytokine levels as biomarkers of coronary artery disease is discussed.
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Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells Physiological and Therapeutic Perspectives
Valérie Planat-Benard,Jean-Sébastien Silvestre,Béatrice Cousin,Mireille André,Maryse Nibbelink,Radia Tamarat,Michel Clergue,Carole Manneville,Corinne Saillan-Barreau,Micheline Duriez,Alain Tedgui,Bernard I. Levy,Luc Pénicaud,Louis Casteilla +13 more
TL;DR: This study demonstrates, for the first time, that adipocytes and endothelial cells have a common progenitor, and highlights the concept that adipose lineage cells represent a suitable new cell source for therapeutic angiogenesis in ischemic disease.
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Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Bart Staels,Wolfgang Koenig,Aida Habib,Régine Merval,Marilyne Lebret,Inés Pineda Torra,Inés Pineda Torra,Philippe Delerive,Philippe Delerive,Abdessamad Fadel,Abdessamad Fadel,Giulia Chinetti,Giulia Chinetti,Jean-Charles Fruchart,Jean-Charles Fruchart,Jamila Najib,Jamila Najib,Jacques Maclouf,Alain Tedgui +18 more
TL;DR: It is concluded that activators of PPARα inhibit the inflammatory response of aortic smooth-muscle cells and decrease the concentration of plasma acute-phase proteins, indicating that PPAR α in the vascular wall may influence the process of atherosclerosis and re-stenosis.
Journal ArticleDOI
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Philippe Delerive,Karolien De Bosscher,Sandrine Besnard,Wim Vanden Berghe,Jeffrey M. Peters,Frank J. Gonzalez,Jean Charles Fruchart,Alain Tedgui,Guy Haegeman,Bart Staels +9 more
TL;DR: Fibrates inhibit the vascular inflammatory response via PPARα by interfering with the NF-κB and AP-1 transactivation capacity involving direct protein-protein interaction with p65 and c-Jun.
Journal ArticleDOI
Natural regulatory T cells control the development of atherosclerosis in mice.
Hafid Ait-Oufella,Benoît L. Salomon,Stephane Potteaux,Anna-Karin L. Robertson,Pierre Gourdy,Joffrey Zoll,Régine Merval,Bruno Esposito,José L. Cohen,Sylvain Fisson,Richard A. Flavell,Göran K. Hansson,David Klatzmann,Alain Tedgui,Ziad Mallat +14 more
TL;DR: It is shown that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models.