Y
Yong-Han Paik
Researcher at Samsung Medical Center
Publications - 139
Citations - 5868
Yong-Han Paik is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Hepatocellular carcinoma & Hepatitis B. The author has an hindex of 30, co-authored 117 publications receiving 4626 citations. Previous affiliations of Yong-Han Paik include University of North Carolina at Chapel Hill & Yonsei University.
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Journal ArticleDOI
Toll-Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Yong-Han Paik,Yong-Han Paik,Robert F. Schwabe,Ramon Bataller,Maria Pia Russo,Christian Jobin,David A. Brenner +6 more
TL;DR: Human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF‐κB and JNK and up‐regulate chemokines and adhesion molecules, and are a potential mediator of LPS‐induced liver injury.
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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
Ramon Bataller,Robert F. Schwabe,Youkyung Hwang Choi,Liu Yang,Yong-Han Paik,Jeffrey N. Lindquist,Ting Qian,Robert Schoonhoven,Curt H. Hagedorn,John J. Lemasters,David A. Brenner,David A. Brenner +11 more
TL;DR: NADPH oxidase mediates the actions of Ang II on HSCs and plays a critical role in liver fibrogenesis, as assessed by microarray analysis.
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Origin of myofibroblasts in the fibrotic liver in mice
Keiko Iwaisako,Chunyan Jiang,Mingjun Zhang,Min Cong,Thomas Moore-Morris,Tae Jun Park,Xiao Liu,Jun Xu,Ping Wang,Yong-Han Paik,Fanli Meng,Masataka Asagiri,Lynne Murray,Alan F. Hofmann,Takashi Iida,Christopher K. Glass,David A. Brenner,Tatiana Kisseleva +17 more
TL;DR: A novel flow cytometry-based method of aPFs purification from the nonparenchymal cell fraction of collagen-α1(I)-GFP mice is developed and potential aPF-specific markers are identified, including a mesothelial-specific marker mesothelin.
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Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma
Won Sohn,Jonghwa Kim,So Hee Kang,Se Ra Yang,Ju Yeon Cho,Hyun Chin Cho,Sang Goon Shim,Yong-Han Paik,Yong-Han Paik +8 more
TL;DR: It is suggested that serum exosomal microRNAs may be used as novel serological biomarkers for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B.
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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.
Tomonori Aoyama,Tomonori Aoyama,Yong-Han Paik,Sumio Watanabe,Benoît Laleu,Francesca Gaggini,Laetitia Fioraso-Cartier,Sophie Molango,Freddy Heitz,Cedric Merlot,Cedric Szyndralewiez,Patrick Page,David A. Brenner +12 more
TL;DR: SOD1mu induces excessive NOX1 activation through Rac1 in HSCs, causing enhanced NOX4 up‐regulation, ROS generation, and liver fibrosis.