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Yong Sam Jung
Researcher at University of California, Davis
Publications - 33
Citations - 1311
Yong Sam Jung is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene knockdown & Regulation of gene expression. The author has an hindex of 20, co-authored 25 publications receiving 1092 citations. Previous affiliations of Yong Sam Jung include Nanjing Agricultural University & Chungnam National University.
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Journal ArticleDOI
Examination of the expanding pathways for the regulation of p21 expression and activity.
TL;DR: The activity of p21 is discussed and current knowledge of the determinants that control p21 transcription, mRNA stability and translation, and protein stability and activity are focused on.
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Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Yanhong Zhang,Yingjuan Qian,Yingjuan Qian,Jin Zhang,Wensheng Yan,Yong Sam Jung,Yong Sam Jung,Mingyi Chen,Eric C. Huang,Kent Lloyd,Yuyou Duan,Jian Wang,Gang Liu,Xinbin Chen +13 more
TL;DR: It is concluded that FDXR and p53 are mutually regulated and that theFDXR-p53 loop is critical for tumor suppression via iron homeostasis.
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Role of Pirh2 in mediating the regulation of p53 and c-Myc.
Anne Hakem,Miyuki Bohgaki,Bénédicte Lemmers,Elisabeth Tai,Leonardo Salmena,Elzbieta Matysiak-Zablocki,Yong Sam Jung,Jana Karaskova,Lilia Kaustov,Shili Duan,Jason Madore,Paul C. Boutros,Yi Sheng,Marta Chesi,P. Leif Bergsagel,Bayardo Perez-Ordonez,Anne Marie Mes-Masson,Linda Z. Penn,Jeremy A. Squire,Xinbin Chen,Igor Jurisica,Cheryl H. Arrowsmith,Otto Sanchez,Samuel Benchimol,Razqallah Hakem +24 more
TL;DR: In vivo roles of Pirh2 in the regulation of p53 and c-Myc stability and its role as a tumor suppressor are revealed and low expression of human PIRH2 in lung, ovarian, and breast cancers correlates with decreased patients' survival.
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Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation
TL;DR: PolH, a target of the p53 tumor suppressor, is a short-half-life protein that is degraded by proteasome, which is enhanced upon UV irradiation and observed that Pirh2 knockdown leads to accumulation of PolH and, subsequently, enhances the survival of UV-irradiated cells.
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p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability.
TL;DR: The mutual regulation between p73 and RNPC1 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional p53.