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Yong Shi
Researcher at Northwestern University
Publications - 17
Citations - 2053
Yong Shi is an academic researcher from Northwestern University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Parkinson's disease. The author has an hindex of 11, co-authored 16 publications receiving 1855 citations.
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Journal ArticleDOI
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
Faisal Fecto,Jianhua Yan,S. Pavan Vemula,Erdong Liu,Yi Yang,Wenjie Chen,Jian Guo Zheng,Yong Shi,Nailah Siddique,Hasan Arrat,Sandra Donkervoort,Senda Ajroud-Driss,Robert L. Sufit,Scott Heller,Han Xiang Deng,Teepu Siddique +15 more
TL;DR: The findings provide evidence of a direct genetic role for p62 in ALS pathogenesis and suggest that regulation of protein degradation pathways may represent an important therapeutic target in motor neuron degeneration.
Journal ArticleDOI
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
Han Xiang Deng,Yong Shi,Yoshiaki Furukawa,Hong Zhai,Ronggen Fu,Erdong Liu,George Gorrie,Mohammad S. Khan,Wu Yen Hung,Eileen H. Bigio,Thomas J. Lukas,Mauro C. Dal Canto,Thomas V. O'Halloran,Teepu Siddique +13 more
TL;DR: Findings provide evidence of direct links among oxidation, protein aggregation, mitochondrial damage, and SOD1-mediated ALS, with possible applications to the aging process and other late-onset neurodegenerative disorders, and rational therapy can now be developed and tested.
Journal ArticleDOI
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4.
Han Xiang Deng,Christopher J. Klein,Jianhua Yan,Yong Shi,Yanhong Wu,Faisal Fecto,Hau Jie Yau,Yi Yang,Hong Zhai,Nailah Siddique,E. Tessa Hedley-Whyte,Robert DeLong,Marco Martina,Peter J. Dyck,Teepu Siddique +14 more
TL;DR: It is reported that SPSMA and CMT2C are allelic disorders caused by mutations in the gene encoding the transient receptor potential cation channel, subfamily V, member 4 (TRPV4), implying a pathogenic mechanism and possible options for therapy for these disorders.
Journal ArticleDOI
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia.
Jianhua Yan,Han Xiang Deng,Nailah Siddique,Faisal Fecto,W. Chen,Yi Yang,Erdong Liu,Sandra Donkervoort,J.G. Zheng,Yong Shi,Kreshnik B. Ahmeti,Benjamin Rix Brooks,W.K. Engel,Teepu Siddique +13 more
TL;DR: FUS gene mutations are not an uncommon cause in patients with FALS from diverse genetic backgrounds, and have a prevalence of 5.6% in non-SOD1 and non-TARDBP FALS, and ∼4.79% in all FALS.
Journal ArticleDOI
Identification of TMEM230 mutations in familial Parkinson's disease
Han Xiang Deng,Yong Shi,Yi Yang,Kreshnik B. Ahmeti,Nimrod Miller,Cao Huang,Lijun Cheng,Hong Zhai,Sheng Deng,Sheng Deng,Karen Nuytemans,Nicola J. Corbett,Myung Jong Kim,Hao Deng,Beisha Tang,Ziquang Yang,Ziquang Yang,Yanming Xu,Piu Chan,Bo Huang,Xiao Ping Gao,Zhi Song,Zhenhua Liu,Faisal Fecto,Nailah Siddique,Tatiana Foroud,Joseph Jankovic,Bernardino Ghetti,Daniel A. Nicholson,Dimitri Krainc,Onur Melen,Jeffery M. Vance,Margaret A. Pericak-Vance,Yong Chao Ma,Ali H. Rajput,Teepu Siddique +35 more
TL;DR: A locus for autosomal dominant, clinically typical and Lewy body-confirmed Parkinson's disease on the short arm of chromosome 20 (20pter-p12) and identify TMEM230 as the disease-causing gene.