W
W. Chen
Researcher at Northwestern University
Publications - 7
Citations - 4325
W. Chen is an academic researcher from Northwestern University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 5, co-authored 5 publications receiving 4103 citations.
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Journal ArticleDOI
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Mark E. Gurney,Haifeng Pu,Arlene Y. Chiu,Mauro C. Dal Canto,Cynthia Y. Polchow,Denise D. Alexander,Jan Caliendo,Afif Hentati,Young W. Kwon,Han Xiang Deng,W. Chen,Ping Zhai,Robert L. Sufit,Teepu Siddique +13 more
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
Journal ArticleDOI
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia.
Jianhua Yan,Han Xiang Deng,Nailah Siddique,Faisal Fecto,W. Chen,Yi Yang,Erdong Liu,Sandra Donkervoort,J.G. Zheng,Yong Shi,Kreshnik B. Ahmeti,Benjamin Rix Brooks,W.K. Engel,Teepu Siddique +13 more
TL;DR: FUS gene mutations are not an uncommon cause in patients with FALS from diverse genetic backgrounds, and have a prevalence of 5.6% in non-SOD1 and non-TARDBP FALS, and ∼4.79% in all FALS.
Journal ArticleDOI
Novel mutations in spastin gene and absence of correlation with age at onset of symptoms.
Afif Hentati,Han Xiang Deng,Hong Zhai,W. Chen,Yi Yang,Wu Yen Hung,Anser C. Azim,Saeed Bohlega,Rup Tandan,C. L. Warner,Nigel G. Laing,Franca Cambi,Hiroshi Mitsumoto,Raymond P. Roos,Rose-Mary Boustany,M. Ben Hamida,F. Hentati,Teepu Siddique +17 more
TL;DR: Five novel mutations in the spastin gene are identified in five families with SPG4 mutations from North America and Tunisia and the absence of correlation between the predicted mutant spASTin protein and age at onset of symptoms is shown.
Journal ArticleDOI
Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: novel sequence variants in ASPM gene
Asma Gul,Muhammad Jawad Hassan,Saqib Mahmood,W. Chen,Safa Rahmani,Muhammad Imran Naseer,Lisa Dellefave,Noor Muhammad,Muhammad Rafiq,Muhammad Rafiq,Muhammad Ansar,Muhammad Ansar,Muhammad Salman Chishti,Ghazanfar Ali,Teepu Siddique,Wasim Ahmad +15 more
TL;DR: Human autosomal recessive primary microcephaly (MCPH) is a rare genetic disorder in which affected individuals are born with reduced brain size and Mutations in the ASPM gene at the MCPH5 locus appear to be the most common cause.
Journal ArticleDOI
Lack of association of VEGF promoter polymorphisms with sporadic ALS
W. Chen,Mohammad Saeed,Haihong Mao,Nailah Siddique,Lisa Dellefave,Wu Yen Hung,Han Xiang Deng,Robert L. Sufit,Scott Heller,Jonathan L. Haines,Margaret A. Pericak-Vance,Teepu Siddique +11 more
TL;DR: The authors did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.