Y
Yong Wen
Researcher at University of Texas MD Anderson Cancer Center
Publications - 18
Citations - 3351
Yong Wen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer cell & Apoptosis. The author has an hindex of 15, co-authored 18 publications receiving 3208 citations. Previous affiliations of Yong Wen include University of Texas Health Science Center at Houston & University of Texas at Austin.
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Journal ArticleDOI
Nuclear localization of EGF receptor and its potential new role as a transcription factor
Shiaw Yih Lin,Keishi Makino,Weiya Xia,Angabin Matin,Yong Wen,Ka Yin Kwong,Lilly Y.W. Bourguignon,Mien Chie Hung +7 more
TL;DR: It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities.
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β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
Shiaw Yih Lin,Weiya Xia,Jo C. Wang,Ka Yin Kwong,Bill Spohn,Yong Wen,Richard G. Pestell,Mien Chie Hung +7 more
TL;DR: It is demonstrated that cyclin D1 is one of the targets of β-catenin in breast cancer cells and may serve as a target for breast cancer therapy and high β-Catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancers.
Journal Article
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Yong Wen,Mickey C.T. Hu,Keishi Makino,Bill Spohn,Geoffrey Bartholomeusz,Duen-Hwa Yan,Mien Chie Hung +6 more
TL;DR: It is reported that HER-2/neu activates Akt (protein kinase B) to promote prostate cancer cell survival and growth in the absence of androgen.
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β-catenin interacts with and inhibits NF-κB in human colon and breast cancer
Jiong Deng,Stephanie A. Miller,Hong Ying Wang,Weiya Xia,Yong Wen,Binhua P. Zhou,Yan Li,Shiaw Yih Lin,Mien Chie Hung +8 more
TL;DR: It is found that β-catenin can physically complex with NF-κB, resulting in a reduction of NF- εκB DNA binding, transactivation activity, and target gene expression, and a strong inverse correlation was identified between the expression levels of β-Catenin and Fas in colon and breast tumor tissues, suggesting thatβ- catenin regulates NF-σκB and its targets in vivo.
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Emodin Down-Regulates Androgen Receptor and Inhibits Prostate Cancer Cell Growth
TL;DR: It is shown that emodin, a natural compound, can directly target AR to suppress prostate cancer cell growth in vitro and prolong the survival of C3(1)/SV40 transgenic mice in vivo.