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Youhe Gao
Researcher at Beijing Normal University
Publications - 204
Citations - 3020
Youhe Gao is an academic researcher from Beijing Normal University. The author has contributed to research in topics: Proteome & Urine. The author has an hindex of 28, co-authored 179 publications receiving 2613 citations. Previous affiliations of Youhe Gao include Peking Union Medical College & Academy of Medical Sciences, United Kingdom.
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Journal ArticleDOI
Defining the Specificity Space of the Human Src Homology 2 Domain
Haiming Huang,Lei Li,Chenggang Wu,David Schibli,Karen Colwill,Sucan Ma,Chengjun Li,Protiva Roy,Krystina Ho,Zhou Songyang,Tony Pawson,Youhe Gao,Shawn S.-C. Li +12 more
TL;DR: The definition of the specificity space of the human SH2 domain provides both the necessary molecular basis and a platform for future exploration of the functions for SH2-containing proteins in cells.
Journal ArticleDOI
Urine—an untapped goldmine for biomarker discovery?
TL;DR: Despite the advantage of urine as a better biomarker source, urine biomarker research can be intimidated by the fact that changes in urine are much too complicated to sort out factors associated with any particular pathophysiologi-cal condition, especially in human samples.
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Physiological conditions can be reflected in human urine proteome and metabolome.
Jianqiang Wu,Youhe Gao +1 more
TL;DR: The effects of common physiological conditions such as gender, age, diet, daily rhythms, exercise, hormone status, lifestyle and extreme environments on human urine are discussed and it is expected that urine will become widely used to detect small and early changes in pathological and/or pharmacological conditions.
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Microwave-assisted Protein Preparation and Enzymatic Digestion in Proteomics
TL;DR: In this study microwave technology was used to develop a fast protein preparation and enzymatic digestion method for protein mixtures, which enabled preparation and digestion ofprotein mixtures in solution or in gel in 6 or 25 min, respectively.
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Human urine proteome analysis by three separation approaches.
TL;DR: The urinary proteome is known to be a valuable field of study related to organ functions, but low molecular mass proteins have not been studied extensively and their post‐translational modification and degradation is unknown.