Z
Zhou Songyang
Researcher at Sun Yat-sen University
Publications - 142
Citations - 10556
Zhou Songyang is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Telomere & Telomere-binding protein. The author has an hindex of 50, co-authored 141 publications receiving 9371 citations. Previous affiliations of Zhou Songyang include Baylor College of Medicine.
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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Puping Liang,Yanwen Xu,Xiya Zhang,Chenhui Ding,Rui Huang,Zhen Zhang,Jie Lv,Xiaowei Xie,Yuxi Chen,Yujing Li,Sun Ying,Yaofu Bai,Zhou Songyang,Wenbin Ma,Canquan Zhou,Junjiu Huang +15 more
TL;DR: It is found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB), however, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic.
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TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
TL;DR: It is demonstrated that TPP1 is a putative mammalian homologue of TEBP-β and contains a predicted amino-terminal oligonucleotide/oligosaccharide binding (OB) fold, and support a yin–yang model in which TPP1 and POT1 function as a unit to protect human telomeres, by both positively and negatively regulating telomerase access to telomere DNA.
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Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
Jiancong Liang,Ma Wan,Yi Zhang,Peili Gu,Peili Gu,Huawei Xin,Sung Yun Jung,Jun Qin,Jiemin Wong,Jiemin Wong,Austin J. Cooney,Dan Liu,Zhou Songyang +12 more
TL;DR: Characterization of endogenous Nanog and Oct4 protein complexes in mouse ES cells found that these transcription factors interact with each other and associate with proteins from multiple repression complexes, including the NuRD, Sin3A and Pml complexes.
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PTOP interacts with POT1 and regulates its localization to telomeres
TL;DR: PTOP binds to the carboxyl terminus of POT1 and recruits it to telomeres, and regulates POT 1 telomeric recruitment and telomere length in human cells.
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Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins
TL;DR: It is found that TRF1 and TRF2 are in fact subunits of a telomere-associated high molecular weight complex (telosome) that also contains POT1, PTOP, RAP1, and TIN2.