Yousef Bo-Abbas

TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.

TL;DR: Mutations in GPR54, a G protein-coupled receptor gene, cause autosomal recessive idiopathic hypogonadotropic hypogOnadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty.

TL;DR: The present study shows the beneficial effects of a long-term ketogenic diet, which significantly reduced the body weight and body mass index of the patients and decreased the level of triglycerides, LDL cholesterol and blood glucose, and increased thelevel of HDL cholesterol.

TL;DR: Observations help to tease apart the neuroendocrine, gonadal, placental and obstetric phenotypes of patients bearing mutations in GPR54.

TL;DR: Investigation of the long-term effect of a ketogenic diet on the activation and modification of heart disease risk factors in obese patients found that elevated levels of triacylglycerols and low levels of HDL were associated with hyperinsulinemia.