Mark Carlton

TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.

TL;DR: Mutations in GPR54, a G protein-coupled receptor gene, cause autosomal recessive idiopathic hypogonadotropic hypogOnadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty.

TL;DR: It is demonstrated that embryos without Stella are compromised in preimplantation development and rarely reach the blastocyst stage, suggesting a similar role for STELLA during early human development as in mice and a potential involvement in germ cell tumors.

TL;DR: It is demonstrated that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPa1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing am Memphisomes to regulate its motility and signaling at the axon terminals.