Y
Yue Shen
Researcher at California Institute of Technology
Publications - 11
Citations - 1326
Yue Shen is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Gene & Bacterial outer membrane. The author has an hindex of 5, co-authored 9 publications receiving 1057 citations.
Papers
More filters
Journal ArticleDOI
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Yue Shen,Maria Letizia Giardino Torchia,Gregory W. Lawson,Christopher L. Karp,Jonathan D. Ashwell,Sarkis K. Mazmanian +5 more
TL;DR: It is demonstrated that OMV-mediated delivery of a commensal molecule prevents disease, uncovering a mechanism of interkingdom communication between the microbiota and mammals.
Journal ArticleDOI
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Hiutung Chu,Arya Khosravi,Indah P. Kusumawardhani,Alice H.K. Kwon,Anilton C. Vasconcelos,Larissa D. Cunha,Anne E. Mayer,Yue Shen,Wei Li Wu,Amal Kambal,Stephan R. Targan,Ramnik J. Xavier,Peter B. Ernst,Douglas R. Green,Dermot P.B. McGovern,Herbert W. Virgin,Sarkis K. Mazmanian +16 more
TL;DR: It is proposed that polymorphisms in susceptibility genes promote disease through defects in “sensing” protective signals from the microbiome, defining a potentially critical gene-environment etiology for IBD.
Book ChapterDOI
Host–Bacterial Symbiosis in Health and Disease
TL;DR: This review synthesizes emerging findings and concepts that describe the mutualism between the microbiota and mammals, specifically emphasizing the role of gut bacteria in shaping an immune response that mediates the balance between health and disease.
Patent
Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
Yue Shen,Sarkis K. Mazmanian +1 more
TL;DR: In this paper, outer membrane vesicles (OMVs) containing PSA were used to prevent experimental colitis and suppress pro-inflammatory cytokine responses in the gut, and indicate that compositions, medicaments, and methods useful for the treatment of inflammation, and more particularly, inflammatory bowel diseases.
Patent
Methods and systems for identifying immunomodulatory substances
TL;DR: A method and system for screening bacteria, products purified or made by bacteria and/or other bacterial substance for anti-inflammatory ability is presented in this paper, where a method and a system is presented for screening the bacteria and products made by them.