G
Gregory W. Lawson
Researcher at University of California, Los Angeles
Publications - 46
Citations - 1937
Gregory W. Lawson is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Spermatogenesis & Molar. The author has an hindex of 21, co-authored 45 publications receiving 1663 citations. Previous affiliations of Gregory W. Lawson include University of California, Davis & University of California, Berkeley.
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Journal ArticleDOI
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Yue Shen,Maria Letizia Giardino Torchia,Gregory W. Lawson,Christopher L. Karp,Jonathan D. Ashwell,Sarkis K. Mazmanian +5 more
TL;DR: It is demonstrated that OMV-mediated delivery of a commensal molecule prevents disease, uncovering a mechanism of interkingdom communication between the microbiota and mammals.
Journal ArticleDOI
Knockout of the transcription factor Nrf2 disrupts spermatogenesis in an age-dependent manner
Brooke N. Nakamura,Gregory W. Lawson,Jefferson Y. Chan,Jesus Banuelos,Mabel M. Cortés,Yvonne D. Hoang,Laura Ortiz,Bogdan A. Rau,Ulrike Luderer +8 more
TL;DR: Evidence that oxidative stress has deleterious effects on the testis and epididymis is provided and a critical role for the transcription factor NRF2 is demonstrated in preventing oxidative disruption of spermatogenesis is demonstrated.
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PTEN dosage is essential for neurofibroma development and malignant transformation
Caroline Gregorian,Jonathan Nakashima,Sarah M. Dry,P Leia Nghiemphu,Kathleen B. Smith,Yan Ao,Julie Dang,Gregory W. Lawson,Ingo K. Mellinghoff,Paul S. Mischel,Michael E. Phelps,Luis F. Parada,Xin Liu,Michael V. Sofroniew,Fritz C. Eilber,Hong Wu +15 more
TL;DR: Using noninvasive in vivo PET-CT imaging, it is demonstrated that FDG can be used to identify the malignant transformation in both murine and human MPNSTs and combined inhibition of RAS/RAF/MAPK and PTEN/PI3K/AKT pathways may be beneficial for patients withMPNST.
Journal ArticleDOI
Protein Inhibitor of Activated STAT Y (PIASy) and a Splice Variant Lacking Exon 6 Enhance Sumoylation but Are Not Essential for Embryogenesis and Adult Life
TL;DR: This study demonstrates that at steady state, PIASy is either dispensable or compensated for by other PIAS family members or by other mechanisms when deleted.
Journal ArticleDOI
Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease.
Vincent Lelievre,Géraldine Favrais,Géraldine Favrais,Catalina Abad,H Adle-Biassette,H Adle-Biassette,Y Lu,Patrizia M. Germano,Gardenia Cheung-Lau,Joseph R. Pisegna,Pierre Gressens,Pierre Gressens,Gregory W. Lawson,James A. Waschek +13 more
TL;DR: It is demonstrated that the overall intestinal morphology and light microscopic structure is significantly altered in VIP(-/-) mice, and there is an overall increase in weight, and decrease in length of the bowel compared to wild type (WT) controls.