Hong Lei

TL;DR: It is suggested that LSD1 demethylates and stabilizes Dnmt1, thus providing a previously unknown mechanistic link between the histone and DNA methylation systems.

TL;DR: It is shown that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling, and R-spondin mimics ZNRF3 inhibition by increasing the membrane level of WNT receptors.

TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.

TL;DR: It is suggested that demethylation of H3K4 is critical for establishing the DNA methylation imprints during oogenesis, and amine oxidase (flavin-containing) domain 1 (AOF1), a protein related to the lysine demethylase KDM1 (also known as LSD1), functions as a histone H3Lysine 4 (H3K 4) demethyl enzyme and is required for de novo DNA methylated genes in oocytes

TL;DR: Results indicate that Dot1L and H3K79 methylation play important roles in heterochromatin formation and in embryonic development.