Yuehan Gong

TL;DR: It is reported that metal hydride nanodots can be used for sonodynamic therapy, which can be further enhanced by photothermal heating to increase tissue oxygenation and enhance intra-tumoral blood flow and improve tumor oxygenation.

TL;DR: This work presents a type of multifunctional sonosensitizer for highly efficient cancer treatment via simply doping TiO2 nanostructures with metal ions in ultrasmall iron-doped titanium oxide nanodots synthesized via a thermal decomposition strategy.

TL;DR: In this article, ultra-small titanium nitride (TiN) nanodots are successfully synthesized for photothermal-enhanced sonodynamic therapy against cancer, which can be used for photoacoustic (PA) imaging and photothermal therapy of tumors.

TL;DR: Doping TiO2 with other special elements is a meaningful strategy to fabricate nanostructures with interesting functions useful in biomedicine, and it is demonstrated that V-TiO2 nanospindles can effectively kill cancer by the combined chemodynamic-sonodynamic therapy, significantly improving the tumor treatment outcomes.

TL;DR: This work highlights a new type of biodegradable sonosensitizer with the ability of regulating TME for applications in cancer theranostics, constructed by a high-temperature organic-solution method and further modified with polyethylene glycol (PEG).