Journal ArticleDOI
V-TiO2 nanospindles with regulating tumor microenvironment performance for enhanced sonodynamic cancer therapy
Xianwen Wang,Xiyu Wang,Xiaoyan Zhong,Guangqiang Li,Zhijuan Yang,Yuehan Gong,Zhuang Liu,Liang Cheng +7 more
TLDR
Doping TiO2 with other special elements is a meaningful strategy to fabricate nanostructures with interesting functions useful in biomedicine, and it is demonstrated that V-TiO2 nanospindles can effectively kill cancer by the combined chemodynamic-sonodynamic therapy, significantly improving the tumor treatment outcomes.Abstract:
Sonodynamic therapy, with advantages in large tissue penetration depth and great controllability, is a promising type of non-invasive cancer treatment method. Developing sonosensitizers with high reactive oxygen species (ROS) quantum yield and the ability to regulate tumor microenvironment to achieve enhanced performances in sonodynamic therapy would thus be rather attractive. Herein, vanadium (V) doped TiO2 (V-TiO2) nanospindles with glutathione-depleting properties are fabricated for enhanced sonodynamic cancer therapy. Due to doping of the V element, the bandgap of V-TiO2 nanospindles is reduced, increasing the efficiency of ultrasound-triggered ROS production compared to that of pure TiO2 nanoparticles. More interestingly, the doping of V also makes V-TiO2 nanospindles an effective Fenton-like agent, which can catalyze the generation of highly toxic hydroxyl radicals (•OH) from endogenous H2O2 in the tumor, thus enabling cancer-killing through chemodynamic therapy. In addition, the V doping also endows V-TiO2 nanospindles with the function of glutathione depletion, further amplifying the oxidative stress generated by chemodynamic-sonodynamic therapy. In vitro cell experiments and in vivo animal experiments demonstrate that V-TiO2 nanospindles can effectively kill cancer by the combined chemodynamic-sonodynamic therapy, significantly improving the tumor treatment outcomes. Importantly, V-TiO2 with the ultrasmall spindle morphology can be quickly excreted from the body, without causing any long-term toxicity. This work illustrates that doping TiO2 with other special elements is a meaningful strategy to fabricate nanostructures with interesting functions useful in biomedicine.read more
Citations
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Journal ArticleDOI
Inorganic nanomaterials with rapid clearance for biomedical applications.
TL;DR: A comprehensive review of the recent progress of biodegradable and clearable inorganic nanomaterials for biomedical applications can be found in this paper, where the future prospects and opportunities in this rapidly growing biomedical field are discussed.
Journal ArticleDOI
Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances.
Chenyang Jia,Yuxin Guo,Fu-Gen Wu +2 more
TL;DR: In this article, the latest advancements in the nanomaterials-involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.
Journal ArticleDOI
Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy.
Xianwen Wang,Qianqian Shi,Zhengbao Zha,Dongdong Zhu,Lirong Zheng,Luoxiang Shi,Xianwen Wei,Lian Lian,Konglin Wu,Liang Cheng +9 more
TL;DR: Wang et al. as discussed by the authors constructed a single-atom sites/N doped porous carbon (Cu SASs/NPC) for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolyysis (PEAP) strategy.
Journal ArticleDOI
Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer
Xianwen Wang,Xiyu Wang,Qingfen Yue,Huizhong Xu,Xiaoyan Zhong,Lina Sun,Guangqiang Li,Yuehan Gong,Nailing Yang,Zhanhui Wang,Zhuang Liu,Liang Cheng +11 more
TL;DR: In this article, ultra-small titanium nitride (TiN) nanodots are successfully synthesized for photothermal-enhanced sonodynamic therapy against cancer, which can be used for photoacoustic (PA) imaging and photothermal therapy of tumors.
Journal ArticleDOI
Interfacially Engineered Zn x Mn 1- x S@Polydopamine Hollow Nanospheres for Glutathione Depleting Photothermally Enhanced Chemodynamic Therapy
Juan Ruan,Juan Ruan,Hang Liu,Benjin Chen,Fei Wang,Wanni Wang,Zhengbao Zha,Haisheng Qian,Zhaohua Miao,Jianan Sun,Tian Tian,Yulong He,Hua Wang +12 more
TL;DR: In this paper, an alternative strategy for fabricating high-performance, multifunctional composite nanostructures for a combined cancer treatment was presented, in which the Fenton-like reactions driven by Mn ions can be tuned by a controllable release of Mn ions in vitro and in vivo.
References
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Journal ArticleDOI
Chemodynamic Therapy: Tumour Microenvironment‑Mediated Fenton and Fenton‑like Reactions
TL;DR: Various strategies based on the Fenton reaction have been employed to enhance hydroxyl radical generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview.
Journal ArticleDOI
Multifunctional sonosensitizers in sonodynamic cancer therapy
Subin Son,Ji Hyeon Kim,Xianwen Wang,Chuangli Zhang,Shin A Yoon,Jinwoo Shin,Amit Sharma,Min Hee Lee,Liang Cheng,Jiasheng Wu,Jong Seung Kim +10 more
TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
Journal ArticleDOI
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Wen-Wen Yue,Liang Chen,Luodan Yu,Bangguo Zhou,Bangguo Zhou,Haohao Yin,Haohao Yin,Wei-Wei Ren,Chang Liu,Le-Hang Guo,Yi-Feng Zhang,Li-Ping Sun,Kun Zhang,Hui-Xiong Xu,Yu Chen +14 more
TL;DR: A nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy is used, and it is found that when used together with anti-PD-L1, tumour formation and metastases are impacted.
Journal ArticleDOI
Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow.
TL;DR: This work provides the paradigm of high therapeutic efficacy of a combined sono-/photoinduced tumor-treatment protocol and significantly broadens the nanomedical applications of semiconductor-based nanoplatforms by rational design of their nanostructures and control of their physiochemical properties.
Journal ArticleDOI
Recent progress of chemodynamic therapy-induced combination cancer therapy
TL;DR: This review begins by defining CDT, then it identifies the problems faced in CDT and proposes various strategies to enhance CDT performance, primarily focusing on CDT-based combined cancer treatment.