Yuichiro J. Suzuki

TL;DR: In a mouse model of OSA, it is found that IH causes time-dependent alterations of the susceptibility of the heart to oxidative stress, and exposure to prolonged IH allowed reversal of the enhancement of myocardial damage.

TL;DR: In this article, the authors investigated the mechanism of increased GATA4 expression in the right ventricle of rats treated with chronic hypoxia to induce pulmonary hypertension and established a right heart-specific signaling mechanism in response to pressure overload, which involves metal-catalyzed carbonylation and degradation of annexin A1 that liberates CBF/NF-Y to activate Gata4 gene transcription.

TL;DR: The results suggest that O2-.

TL;DR: It is demonstrated that bleomycin, a chemotherapeutic agent which induces pulmonary fibrosis in animals and humans, increases gene expression of angiotensin-converting enzyme (ACE) through the MAPK pathway and Egr-1.

TL;DR: O2-induced inactivation of rabbit muscle CK was accompanied by a decrease in its thiol group content, whereas no significant changes in the protein structure were detected by SDS-PAGE or carbonyl content, suggesting that oxidation of -SH groups by H2O2 seems to be a major mechanism of activation of rabbit Muscle CK by xanthine + xanthin oxidase.