Y
Yun Zhao
Researcher at Chinese Academy of Sciences
Publications - 134
Citations - 5499
Yun Zhao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Hedgehog signaling pathway & Hippo signaling pathway. The author has an hindex of 33, co-authored 120 publications receiving 4620 citations. Previous affiliations of Yun Zhao include University of Science and Technology of China & ShanghaiTech University.
Papers
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Journal ArticleDOI
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Xiao-Qing Liu,Yun Zhao,Jiangang Gao,Basil S. Pawlyk,Barry Starcher,Jeffrey A. Spencer,Hiromi Yanagisawa,J. Zuo,Tiansen Li +8 more
TL;DR: It is shown that mice lacking the protein lysyl oxidase–like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation.
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A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
Shi Jiao,Huizhen Wang,Zhubing Shi,Aimei Dong,Wenjing Zhang,Xiaomin Song,Feng He,Yicui Wang,Zhenzhen Zhang,Wenjia Wang,Xin Wang,Tong Guo,Peixue Li,Yun Zhao,Hongbin Ji,Lei Zhang,Zhaocai Zhou +16 more
TL;DR: It is found that VGLL4 directly competes with YAP for binding TEADs and this finding suggests that disruption of YAP-TEADs interaction by aVGLL4-mimicking peptide may be a promising therapeutic strategy against Yap-driven human cancers.
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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Joel M. Hyman,Ari J. Firestone,Vivi M. Heine,Yun Zhao,Cory A. Ocasio,Kyuho Han,Mark Sun,Paul G. Rack,Surajit Sinha,Surajit Sinha,Jason Wu,David E. Solow-Cordero,Jin Jiang,David H. Rowitch,James K. Chen +14 more
TL;DR: Four Hh pathway antagonists that are epistatic to the nucleocytoplasmic regulator Suppressor of Fused are reported, including two that can inhibit Hh target gene expression induced by overexpression of the Gli transcription factors and reveal that Gli processing, Gli activation, and primary cilia formation are pharmacologically targetable.
Journal ArticleDOI
Hedgehog regulates smoothened activity by inducing a conformational switch
TL;DR: Evidence that phosphorylation activates SMO by inducing a conformational switch is provided and SMO acts as a rheostat to translate graded HH signals into distinct responses, which is essential for pathway activation.
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The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: Subserving RPGR function and participating in disk morphogenesis
Yun Zhao,Dong-Hyun Hong,Basil S. Pawlyk,Guohua Yue,Michael Adamian,Marcin Grynberg,Adam Godzik,Tiansen Li +7 more
TL;DR: It is concluded that RPGRIP is a stable polymer in the CC where it tethers RPGR and that RPGR depends on RPGRIP for subcellular localization and normal function, and thatRPGRIP is also required for disk morphogenesis, putatively by regulating actin cytoskeleton dynamics.