J
Jin Jiang
Researcher at University of Texas Southwestern Medical Center
Publications - 101
Citations - 13482
Jin Jiang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Smoothened & Hedgehog signaling pathway. The author has an hindex of 49, co-authored 101 publications receiving 12419 citations. Previous affiliations of Jin Jiang include Kunming Institute of Zoology & Stanford University.
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Journal ArticleDOI
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jin Jiang,Gary Struhl +1 more
TL;DR: A new gene is described, slimb (for supernumerary limbs), which negatively regulates both of these signal transduction pathways and encodes a conserved F-box/WD40-repeat protein related to Cdc4p, a protein in budding yeast that targets cell-cycle regulators for degradation by the ubiquitin/proteasome pathway.
Journal ArticleDOI
Hedgehog signaling in development and cancer.
Jin Jiang,Chi-chung Hui +1 more
TL;DR: The current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of HH signaling in development and tumorigenesis are reviewed.
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The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.
TL;DR: Evidence is provided that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes, forming a transcriptional complex whose activity is inhibited by Hpo signaling.
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Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
Hai Song,Kinglun Kingston Mak,Lilia Topol,Kangsun Yun,Jianxin Hu,Lisa Garrett,Yongbin Chen,Ogyi Park,Jia Chang,R. Mark Simpson,Cun-Yu Wang,Bin Gao,Jin Jiang,Yingzi Yang +13 more
TL;DR: It is found that Mst1 and Mst2, the two mouse homologs of the Drosophila Hpo, control the sizes of some, but not all organs, in mice, and MSt1 andMst2 act as tumor suppressors by restricting cell proliferation and survival.
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Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila
TL;DR: It is found that the insulin receptor signaling pathway is required for intestinal stem cell division, and if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells.