H
Hongbin Ji
Researcher at Chinese Academy of Sciences
Publications - 188
Citations - 15734
Hongbin Ji is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 58, co-authored 172 publications receiving 13120 citations. Previous affiliations of Hongbin Ji include Beth Israel Deaconess Medical Center & Tongji University.
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Journal ArticleDOI
ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers
Kristin Bergethon,Alice T. Shaw,Sai-Hong Ignatius Ou,Ryohei Katayama,Christine M. Lovly,Nerina T. McDonald,Pierre P. Massion,Christina Siwak-Tapp,Adriana Gonzalez,Rong Fang,Eugene J. Mark,Julie M. Batten,Haiquan Chen,Keith D. Wilner,Eunice L. Kwak,Jeffrey W. Clark,David P. Carbone,Hongbin Ji,Jeffrey A. Engelman,Mari Mino-Kenudson,William Pao,A. John Iafrate +21 more
TL;DR: ROS1 rearrangement defines a molecular subset of NSCLC with distinct clinical characteristics that are similar to those observed in patients with ALK-rearranged NSCLCs, and crizotinib shows in vitro activity and early evidence of clinical activity in ROS1- rearrangedNSCLC.
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LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji,Matthew R. Ramsey,D. Neil Hayes,Cheng Fan,Kate McNamara,Piotr Kozlowski,Chad Torrice,Michael C. Wu,Takeshi Shimamura,Samanthi A. Perera,Mei-Chih Liang,Dongpo Cai,George N. Naumov,Lei Bao,Cristina Contreras,Danan Li,Liang Chen,Janakiraman Krishnamurthy,Jussi Koivunen,Lucian R. Chirieac,Robert F. Padera,Roderick T. Bronson,Neal I. Lindeman,David C. Christiani,Xihong Lin,Geoffrey I. Shapiro,Pasi A. Jänne,Bruce E. Johnson,Matthew Meyerson,David J. Kwiatkowski,Diego H. Castrillon,Nabeel Bardeesy,Norman E. Sharpless,Kwok-Kin Wong +33 more
TL;DR: LKB1 is established as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis in lung cancer, and expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes as targets of LKB1 repression.
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Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth
A. McGarry Houghton,Danuta M Rzymkiewicz,Hongbin Ji,Alyssa D. Gregory,Eduardo E. Egea,Heather E. Metz,Donna B. Stolz,Stephanie R. Land,Luiz A. Marconcini,Corrine R. Kliment,Kimberly M. Jenkins,Keith A Beaulieu,Majd Mouded,Stuart J. Frank,Kwok K. Wong,Steven D. Shapiro +15 more
TL;DR: This study identifies IRS-1 as a key regulator of PI3K within malignant cells within lung adenocarcinomas and describes the first description of a secreted proteinase gaining access to the inside of a cell and altering intracellular signaling.
Journal ArticleDOI
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
Shi Jiao,Huizhen Wang,Zhubing Shi,Aimei Dong,Wenjing Zhang,Xiaomin Song,Feng He,Yicui Wang,Zhenzhen Zhang,Wenjia Wang,Xin Wang,Tong Guo,Peixue Li,Yun Zhao,Hongbin Ji,Lei Zhang,Zhaocai Zhou +16 more
TL;DR: It is found that VGLL4 directly competes with YAP for binding TEADs and this finding suggests that disruption of YAP-TEADs interaction by aVGLL4-mimicking peptide may be a promising therapeutic strategy against Yap-driven human cancers.
Journal ArticleDOI
RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer
Rui Wang,Haichuan Hu,Yunjian Pan,Yuan Li,Ting Ye,Chenguang Li,Xiaoyang Luo,Lei Wang,Hang Li,Yang Zhang,Fei Li,Yongming Lu,Qiong Lu,Jie Xu,David H. Garfield,Lei Shen,Hongbin Ji,William Pao,Yihua Sun,Haiquan Chen +19 more
TL;DR: The RET fusion gene occurs in 1.4% of NSCLCs and 1.7% of lung adenocarcinomas and has identifiable clinicopathologic characteristics, warranting further clinical consideration and targeted therapy investigation.