Yung-Chi Cheng

TL;DR: The 2,6-diaminopurine Z-prodrug seems to be the best candidate for further development and was the most potent against HIV-1 and HBV and somewhat less against HHV-6, HCMV, EBV and VZV in a non-cytotoxic concentration range.

TL;DR: It was shown that NH2 terminus-truncated topoisomerase I (amino acids 201-765) showed at least 4-fold less sensitivity to camptothecin than full-length topoisomersase I in the oligonucleotide religation assay, which implies that PARP-1 and PARp-1/NAD actions need to be highly regulated by cellular factors to exert its cytotoxicity inside the cells.

TL;DR: When tested alone, 5'-ethynylthymidine exhibited no antiviral activity, but it antagonized the antiviral efficacy of five compounds which require viral thymidine kinase for their action.

TL;DR: The Z- and E-isomers of fluoromethylenecyclopropane analogues 11 a-d and 12a-d were synthesized, and their antiviral activities were evaluated, and all of the analogues with the exception of 12d were effective at least in one of the assays against Epstein-Barr virus.

TL;DR: Only 3'-deoxy-3'-C-(hydroxymethyl)thymidine (36) was found to show significant anticancer activity against L1210, P388, S-180, and CCRF-CEM cells with ED50 values of 50, 5, 10, and 1 microM, respectively.