Y
Yung-Chi Cheng
Researcher at Yale University
Publications - 834
Citations - 44358
Yung-Chi Cheng is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 87, co-authored 683 publications receiving 42508 citations. Previous affiliations of Yung-Chi Cheng include University of Georgia & Vion Pharmaceuticals, Inc..
Papers
More filters
Journal ArticleDOI
Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach
TL;DR: In this article, comparative molecular field analysis (CoMFA) and a novel CoMFA/q2-GRS technique were used to identify the essential structural requirements for increasing the ability of these compounds to form cellular protein−DNA complex.
Journal ArticleDOI
A Phase I Study of the Chinese Herbal Medicine PHY906 as a Modulator of Irinotecan-based Chemotherapy in Patients with Advanced Colorectal Cancer
Shivaani Kummar,M. Sitki Copur,Michal G. Rose,Scott Wadler,Joe Stephenson,Mark O'Rourke,Wayne Brenckman,Robert Tilton,Shwu-Huey Liu,Zaoli Jiang,Tahmun Su,Yung-Chi Cheng,Edward Chu +12 more
TL;DR: A phase I multicenter, double-blind, randomized, placebo-controlled, dose escalation, cross-over study of PHY906 as a modulator of the weekly, bolus regimen of irinotecan, 5-FU, and LV (IFL) in the first-line treatment of patients with advanced colorectal cancer (CRC) was conducted.
Journal ArticleDOI
Effect of phosphorothioate homo-oligodeoxynucleotides on herpes simplex virus type 2-induced DNA polymerase.
TL;DR: Phosphorothioate oligonucleotides could be anti-template inhibitors of HSV DNA polymerase, which may lead to the development of a new class of selective anti-HSV agents.
Journal ArticleDOI
Characterization of abnormal thymidine kinases induced by drug-resistant strains of herpes simplex virus type 1.
TL;DR: Each mutant displayed a characteristically distinct pattern of affinities for a range of nucleoside analogue substrates, suggesting that they will show some cross-resistance to drugs which have a similar mechanism of action to acyclovir and BVdU.
Journal ArticleDOI
Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Kuo Hsiung Lee,Scott A. Beers,Masami Mori,Zhe Qing Wang,Yao Haur Kuo,Li Li,Su Ying Liu,Su Ying Liu,Jang Yang Chang,Jang Yang Chang,Fu Sheng Han,Fu Sheng Han,Yung-Chi Cheng,Yung-Chi Cheng +13 more
TL;DR: The cytotoxicity in KB cells appears to have no direct correlation with compounds' ability to inhibit DNA topoisomerase II and to cause protein-linked DNA breaks in cells.